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Evolutionary drivers of antibiotic resistance in Pseudomonas aeruginosa populations from critically ill patients (ID Epi Seminar Series)
March 31 @ 1:00 pm - 2:00 pm
Professor Craig MacLean has a longstanding interest in understanding how ecological and genetic processes interact to drive adaptation in microbial populations. His doctoral research at McGill University (2000-2004) investigated the causes of metabolic adaptive radiation in Pseudomonas fluorescens using experimental evolution. His postdoctoral work at Imperial College London (2005-2007) investigated metabolic cooperation and competition in yeasts. Prof. MacLean moved to Oxford as a lecturer in the Department of Zoology in 2007 and was able to establish his own research group when he was awarded a University Research Fellowship from the Royal Society in 2009. Early research in the MacLean lab focused on studying the evolutionary drivers of antibiotic resistance in pathogenic bacteria using a combination of experimental evolution, genomics, and mathematical modelling. More recently, they have shifted the emphasis of their work to studying the drivers of resistance in clinical settings.
- Wheatley et al. (2021). Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection.
- Wheatley et al. (2022). Assessing the contribution of gut-to-lung translocation to bacterial colonization and antibiotic resistance in an ICU patient.
- Wheatley et al. (2021). Polyclonal pathogen populations accelerate the evolution of antibiotic resistance in patients.