Leading with Science: One Year After Hurricane Maria

On the anniversary of Hurricane Maria in Puerto Rico CCDD’s Prof. Caroline Buckee and colleagues came together in a panel discussion “Beyond Hurricane Maria: Leading With Science” hosted by Harvard FXB Center for Health and Human Rights. The panelists discussed the motivation and rationale for the study, the significance of their findings, the impact of their research, and their decision to release all their data and code online. You can…

Make A Flu Shot Your Halloween Tradition

CCDD Director Prof. Lipsitch is featured in an interview to FiveThirtyEight sharing his views about flu, vaccination and best timing for it. According the Dr. Lipsitch there are several studies showing that the effectiveness of the flu vaccine wanes towards the end of the season. The bottom line- it is better to get the vaccine later in the season as you have better chances of being protected from flu. Related…

Puerto Rico’s Hurricane Maria Death Toll Could Exceed 4,000, New Study Estimates

In a New England Journal of Medicine study, CCDD researchers, Prof. Caroline Buckee, Nishant Kishore, Ayesha Mahmud, and Mathew Kiang, along with others from Harvard and Puerto Rico, found that residents of Puerto Rico died at a significantly higher rate during the three months after Hurricane Maria than they did in the previous year. The researchers conducted more than 3,000 household surveys and found that one third of deaths reported were attributed…

Vaccines Are Pushing Pathogens to Evolve

In a new Quanta Magazine article, “Vaccines are Pushing Pathogens to Evolve”, Dr. Bill Hanage reflects on his days as a young scientist with the introduction of the Prevenar 7 vaccine in the early 2000s. “It struck me, with my almost complete lack of formal training in evolutionary biology, that this was an extraordinary evolutionary experiment,” he said. This now forms the basis for much of his work on how pneumococcus…

CCDD Highlighted on 80,000 Hours Podcast

A new podcast from 80,000 Hours cites CCDD Director Marc Lipsitch’s research group as a great place to work on the quantitative / epidemiologic aspects of pandemics and health security. The podcast is an interview with Dr. Tom Inglesby, Director of the Johns Hopkins Center for Health Security. This echoes a recommendation made on a previous episode of the same podcast by another guest, Howie Lempel.

Influenza Vaccine Effectiveness Against Influenza A(H3N2) Hospitalizations in Children in Hong Kong in a Prolonged Season, 2016/2017. J Infect Dis.

Chiu SS, Kwan MYW, Feng S, Wong JSC, Leung CW, Chan ELY, Chan KH, Ng TK, To WK, Cowling BJ, Peiris JSM. J Infect Dis. 2018 Apr 11;217(9):1365-1371. doi: 10.1093/infdis/jiy027. Read on PubMed Abstract:  BACKGROUND: Influenza A(H3N2) viruses circulated for 12 consecutive months in Hong Kong in 2016-2017, peaking in late June and July 2017. The objective of our study was to estimate the effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong. METHODS: We conducted a test-negative study…

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome. PLoS Pathog.

Azarian T, Grant LR, Arnold BJ, Hammitt LL, Reid R, Santosham M, Weatherholtz R, Goklish N, Thompson CM, Bentley SD, O’Brien KL, Hanage WP, Lipsitch M. PLoS Pathog. 2018 Apr 4;14(4):e1006966. doi: 10.1371/journal.ppat.1006966. Read publication here. Abstract: In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination also disrupts the composition of the pneumococcal pangenome, which includes mobile genetic elements and polymorphic non-capsular antigens important for virulence, transmission, and pneumococcal ecology. Antigenic proteins…

CCDD Publication Selected as Article of the Year- AJE

Congratulations to researchers Colin Worby, Marc Lipsitch and Bill Hanage, whose recent CCDD publication was selected by the Society for Epidemiologic Research and the American Journal of Epidemiology as one of ten articles of the year. Lipsitch and Hanage are CCDD faculty members, and Worby is an alumni of the Center, now at Princeton. Worby CJ, Lipsitch M, Hanage WP. Shared genomic variants: identification of transmission routes using pathogen deep-sequence data. Am J Epidemiol.2017;186(10):1209–1216. Read the full…

Mumps resurgence likely due to waning vaccine-derived immunity

“A resurgence of mumps in the U.S. among vaccinated young adults appears to be due to waning of vaccine-induced immunity, according to a new analysis from Harvard T.H. Chan School of Public Health. Featured work of CCDD researchers Joseph Lewnard and Yonaton Grad. Mumps resurgence likely due to waning vaccine-derived immunity