Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae. Author(s): Lehtinen S, Chewapreecha C, Lees J, Hanage WP, Lipsitch M, Croucher NJ, Bentley SD, Turner P, Fraser C, Mostowy RJ|Journal: Sci Adv|PMID: 32671212| May 2020 The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move…
Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes. Author(s): Chewapreecha C, Marttinen P, Croucher NJ, Salter SJ, Harris SR, Mather AE, Hanage WP, Goldblatt D, Nosten FH, Turner C, Turner P, Bentley SD, Parkhill J|Journal: PLoS Genet|PMID: 25101644| August 2014 Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks,…