Publications – Center for Communicable Disease Dynamics

Genomic epidemiology of meticillin-resistant Staphylococcus aureus ST22 widespread in communities of the Gaza Strip, 2009.

Author(s): Chang Q, Abuelaish I, Biber A, Jaber H, Callendrello A, Andam CP, Regev-Yochay G, Hanage WP, On Behalf Of The Picr Study GroupJournal: Euro SurveillPMID: 30153881 August 2018

BackgroundRemarkably high carriage prevalence of a community-associated meticillin-resistant (MRSA) strain of sequence type (ST) 22 in the Gaza strip was…

Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in Malawi.

Author(s): Chaguza C, Cornick JE, Andam CP, Gladstone RA, Alaerts M, Musicha P, Peno C, Bar-Zeev N, Kamng'ona AW, Kiran AM, Msefula CL, McGee L, Breiman RF, Kadioglu A, French N, Heyderman RS, Hanage WP, Bentley SD, Everett DBJournal: VaccinePMID: 28711389 August 2017

Pneumococcal infections cause a high death toll in Sub Saharan Africa (SSA) but the recently rolled out pneumococcal conjugate vaccines…

Penicillin Resistance of Nonvaccine Type Pneumococcus before and after PCV13 Introduction, United States.

Author(s): Andam CP, Worby CJ, Gierke R, McGee L, Pilishvili T, Hanage WPJournal: Emerg Infect DisPMID: 28518018 June 2017

Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of…

Efficient Inference of Recent and Ancestral Recombination within Bacterial Populations.

Author(s): Mostowy R, Croucher NJ, Andam CP, Corander J, Hanage WP, Marttinen PJournal: Mol Biol EvolPMID: 28199698 May 2017

Prokaryotic evolution is affected by horizontal transfer of genetic material through recombination. Inference of an evolutionary tree of bacteria thus…

Genomic Epidemiology of Penicillin-Nonsusceptible Pneumococci with Nonvaccine Serotypes Causing Invasive Disease in the United States.

Author(s): Andam CP, Mitchell PK, Callendrello A, Chang Q, Corander J, Chaguza C, McGee L, Beall BW, Hanage WPJournal: J Clin MicrobiolPMID: 28100596 April 2017

Conjugate vaccination against seven pneumococcal serotypes (PCV7) reduced disease prevalence due to antibiotic-resistant strains throughout the 2000s. However, diseases caused…

Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms.

Author(s): Harms K, Lunnan A, Hülter N, Mourier T, Vinner L, Andam CP, Marttinen P, Fridholm H, Hansen AJ, Hanage WP, Nielsen KM, Willerslev E, Johnsen PJJournal: Proc Natl Acad Sci U S APMID: 27956618 December 2016

In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels…

Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule.

Author(s): Chaguza C, Andam CP, Harris SR, Cornick JE, Yang M, Bricio-Moreno L, Kamng'ona AW, Parkhill J, French N, Heyderman RS, Kadioglu A, Everett DB, Bentley SD, Hanage WPJournal: MBioPMID: 27677790 September 2016

Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many…

Mechanisms of genome evolution of Streptococcus.

Author(s): Andam CP, Hanage WPJournal: Infect Genet EvolPMID: 25461843 July 2015

The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent…