Author(s): Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M|Journal: MBio|PMID:26374118| September 2015
Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease.…
Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID:25956132| May 2015
Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…
Author(s): Li Y, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID:24082074| December 2013
Streptococcus pneumoniae (pneumococcus) is a significant pathogen that frequently colonizes the human nasopharynx. Environmental factors, including antimicrobial use and host…
Author(s): Li Y, Weinberger DM, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID:24082068| December 2013
Streptococcus pneumoniae (pneumococcus) frequently colonizes the human nasopharynx and is an important cause of pneumonia, meningitis, sinusitis, and otitis media.…
Author(s): Hyams C, Trzciński K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS|Journal: Infect Immun|PMID:23147038| January 2013
Different capsular serotypes of Streptococcus pneumoniae vary markedly in their ability to cause invasive infection, but the reasons why are…
Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID:23144610| January 2012
Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…
Author(s): Regev-Yochay G, Hanage WP, Trzciński K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R|Journal: Vaccine|PMID:20434550| July 2010
Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the…
Author(s): Bogaert D, Thompson CM, Trzciński K, Malley R, Lipsitch M|Journal: Vaccine|PMID:19892042| January 2010
Streptococcus pneumoniae is an important bacterial cause of sepsis, meningitis, pneumonia and otitis media. Pneumococcal disease is generally preceded by…
