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Publications

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Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model.

Author(s): Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M|Journal: MBio|PMID: 26374118| September 2015
Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease.…

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.

Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID: 25956132| May 2015
Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…

Within-host selection is limited by an effective population of Streptococcus pneumoniae during nasopharyngeal colonization.

Author(s): Li Y, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID: 24082074| December 2013
Streptococcus pneumoniae (pneumococcus) is a significant pathogen that frequently colonizes the human nasopharynx. Environmental factors, including antimicrobial use and host…

Surface charge of Streptococcus pneumoniae predicts serotype distribution.

Author(s): Li Y, Weinberger DM, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID: 24082068| December 2013
Streptococcus pneumoniae (pneumococcus) frequently colonizes the human nasopharynx and is an important cause of pneumonia, meningitis, sinusitis, and otitis media.…

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.

Author(s): Hyams C, Trzciński K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS|Journal: Infect Immun|PMID: 23147038| January 2013
Different capsular serotypes of Streptococcus pneumoniae vary markedly in their ability to cause invasive infection, but the reasons why are…

Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID: 23144610| January 2012
Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…

Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA.

Author(s): Regev-Yochay G, Hanage WP, Trzciński K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R|Journal: Vaccine|PMID: 20434550| July 2010
Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the…

The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model.

Author(s): Bogaert D, Thompson CM, Trzciński K, Malley R, Lipsitch M|Journal: Vaccine|PMID: 19892042| January 2010
Streptococcus pneumoniae is an important bacterial cause of sepsis, meningitis, pneumonia and otitis media. Pneumococcal disease is generally preceded by…
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