Publications

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Author(s): Watkins ER, Penman BS, Lourenço J, Buckee CO, Maiden MC, Gupta S|Journal: PLoS Pathog|PMID: 26181911| July 2015

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines…

Pathogen selection drives nonoverlapping associations between HLA loci.

Author(s): Penman BS, Ashby B, Buckee CO, Gupta S|Journal: Proc Natl Acad Sci U S A|PMID: 24225852| November 2013

Pathogen-mediated selection is commonly invoked as an explanation for the exceptional polymorphism of the HLA gene cluster, but its role…

The emergence and maintenance of sickle cell hotspots in the Mediterranean.

Author(s): Penman BS, Gupta S, Buckee CO|Journal: Infect Genet Evol|PMID: 22704979| October 2012

Genetic disorders of haemoglobin (haemoglobinopathies), including the thalassaemias and sickle cell anaemia, abound in historically malarious regions, due to the…