Publications – Center for Communicable Disease Dynamics

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Author(s): Watkins ER, Penman BS, Lourenço J, Buckee CO, Maiden MC, Gupta SJournal: PLoS PathogPMID: 26181911 July 2015

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines…

Modelling challenges in context: lessons from malaria, HIV, and tuberculosis.

Author(s): Childs LM, Abuelezam NN, Dye C, Gupta S, Murray MB, Williams BG, Buckee COJournal: EpidemicsPMID: 25843394 March 2015

Malaria, HIV, and tuberculosis (TB) collectively account for several million deaths each year, with all three ranking among the top…

Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires.

Author(s): Watkins ER, Grad YH, Gupta S, Buckee COJournal: Sci RepPMID: 25296566 October 2014

Pathogen evolution is influenced strongly by the host immune response. Previous studies of the effects of herd immunity on the…

Pathogen selection drives nonoverlapping associations between HLA loci.

Author(s): Penman BS, Ashby B, Buckee CO, Gupta SJournal: Proc Natl Acad Sci U S APMID: 24225852 November 2013

Pathogen-mediated selection is commonly invoked as an explanation for the exceptional polymorphism of the HLA gene cluster, but its role…

The emergence and maintenance of sickle cell hotspots in the Mediterranean.

Author(s): Penman BS, Gupta S, Buckee COJournal: Infect Genet EvolPMID: 22704979 October 2012

Genetic disorders of haemoglobin (haemoglobinopathies), including the thalassaemias and sickle cell anaemia, abound in historically malarious regions, due to the…

Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations.

Author(s): Buckee CO, Recker M, Watkins ER, Gupta SJournal: Proc Natl Acad Sci U S APMID: 21876129 September 2011

Many highly diverse pathogen populations appear to exist stably as discrete antigenic types despite evidence of genetic exchange. It has…

Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

Author(s): Recker M, Buckee CO, Serazin A, Kyes S, Pinches R, Christodoulou Z, Springer AL, Gupta S, Newbold CIJournal: PLoS PathogPMID: 21408201 March 2011

Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the…

Long-term evolution of antigen repertoires among carried meningococci.

Author(s): Buckee CO, Gupta S, Kriz P, Maiden MC, Jolley KAJournal: Proc Biol SciPMID: 20129981 June 2010

Most studies of bacterial pathogen populations have been based on isolates collected from individuals with disease, or their contacts, over…

Modelling malaria population structure and its implications for control.

Author(s): Buckee CO, Gupta SJournal: Adv Exp Med BiolPMID: 20632533 January 2010

Mathematical models of malaria transmission have been used to inform the design of malaria control programs since the mid 20th…