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Publications

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Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Author(s): Watkins ER, Penman BS, Lourenço J, Buckee CO, Maiden MC, Gupta S|Journal: PLoS Pathog|PMID: 26181911| July 2015
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines…

Modelling challenges in context: lessons from malaria, HIV, and tuberculosis.

Author(s): Childs LM, Abuelezam NN, Dye C, Gupta S, Murray MB, Williams BG, Buckee CO|Journal: Epidemics|PMID: 25843394| March 2015
Malaria, HIV, and tuberculosis (TB) collectively account for several million deaths each year, with all three ranking among the top…

Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires.

Author(s): Watkins ER, Grad YH, Gupta S, Buckee CO|Journal: Sci Rep|PMID: 25296566| October 2014
Pathogen evolution is influenced strongly by the host immune response. Previous studies of the effects of herd immunity on the…

Pathogen selection drives nonoverlapping associations between HLA loci.

Author(s): Penman BS, Ashby B, Buckee CO, Gupta S|Journal: Proc Natl Acad Sci U S A|PMID: 24225852| November 2013
Pathogen-mediated selection is commonly invoked as an explanation for the exceptional polymorphism of the HLA gene cluster, but its role…

The emergence and maintenance of sickle cell hotspots in the Mediterranean.

Author(s): Penman BS, Gupta S, Buckee CO|Journal: Infect Genet Evol|PMID: 22704979| October 2012
Genetic disorders of haemoglobin (haemoglobinopathies), including the thalassaemias and sickle cell anaemia, abound in historically malarious regions, due to the…

Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations.

Author(s): Buckee CO, Recker M, Watkins ER, Gupta S|Journal: Proc Natl Acad Sci U S A|PMID: 21876129| September 2011
Many highly diverse pathogen populations appear to exist stably as discrete antigenic types despite evidence of genetic exchange. It has…

Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

Author(s): Recker M, Buckee CO, Serazin A, Kyes S, Pinches R, Christodoulou Z, Springer AL, Gupta S, Newbold CI|Journal: PLoS Pathog|PMID: 21408201| March 2011
Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the…

Long-term evolution of antigen repertoires among carried meningococci.

Author(s): Buckee CO, Gupta S, Kriz P, Maiden MC, Jolley KA|Journal: Proc Biol Sci|PMID: 20129981| June 2010
Most studies of bacterial pathogen populations have been based on isolates collected from individuals with disease, or their contacts, over…

Modelling malaria population structure and its implications for control.

Author(s): Buckee CO, Gupta S|Journal: Adv Exp Med Biol|PMID: 20632533| January 2010
Mathematical models of malaria transmission have been used to inform the design of malaria control programs since the mid 20th…

Center for Communicable Disease Dynamics on Twitter

  • RT @mena_gonzalo: Acá una muestra preliminar sobre nuestra caracterización del impacto del COVID-19 (en incidencia y mortalidad) en Santiag…
  • RT @PamelaPMartinez: New paper! Socioeconomic status DETERMINES COVID-19 incidence and related mortality in Santiago, Chile https://t.co/en…
  • RT @PamelaPMartinez: New paper! Socioeconomic status DETERMINES COVID-19 incidence and related mortality in Santiago, Chile https://t.co/en…
  • RT @PamelaPMartinez: New paper! Socioeconomic status DETERMINES COVID-19 incidence and related mortality in Santiago, Chile https://t.co/en…
  • RT @PamelaPMartinez: New paper! Socioeconomic status DETERMINES COVID-19 incidence and related mortality in Santiago, Chile https://t.co/en…
  • RT @PamelaPMartinez: New paper! Socioeconomic status DETERMINES COVID-19 incidence and related mortality in Santiago, Chile https://t.co/en…
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