Classic reaction kinetics can explain complex patterns of antibiotic action.

Author(s): Abel zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen TJournal: Sci Transl MedPMID: 25972005 May 2015
Finding optimal dosing strategies for treating bacterial infections is extremely difficult, and improving therapy requires costly and time-intensive experiments. To…

Sequence tag-based analysis of microbial population dynamics.

Author(s): Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MKJournal: Nat MethodsPMID: 25599549 March 2015
We describe sequence tag-based analysis of microbial populations (STAMP) for characterization of pathogen population dynamics during infection. STAMP analyzes the…