Publications – Center for Communicable Disease Dynamics

CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae.

Author(s): Rubin DHF, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YHJournal: Nat MicrobiolPMID: 36604513 January 2023

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…

Recent O-antigen diversification masks highly pathogenic STEC O104:H4

Author(s): Lang C, Fruth A, Campbell IW, Jenkins C, Smith P, Strockbine N, Weill FX, Nübel U, Grad YH, Waldor MK, Flieger AJournal: bioRxiv October 2022

Shiga toxin-producing E. coli (STEC) can give rise to a range of clinical outcomes from diarrhea to the life-threatening systemic…

Variation in supplemental carbon dioxide requirements defines lineage-specific antibiotic resistance acquisition in Neisseria gonorrhoeae

Author(s): Rubin DH, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YHJournal: bioRxiv February 2022

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…

Testing COVID-19 therapies to prevent progression of mild disease.

Author(s): Lipsitch M, Waldor MKJournal: Lancet Infect DisPMID: 32618282 May 2020

A randomised controlled trial found no significant benefit of lopinavir-ritonavir over placebo in patients with severe corona-virus disease 2019 (COVID-19). Even…

Sequence tag-based analysis of microbial population dynamics.

Author(s): Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MKJournal: Nat MethodsPMID: 25599549 March 2015

We describe sequence tag-based analysis of microbial populations (STAMP) for characterization of pathogen population dynamics during infection. STAMP analyzes the…

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen.

Author(s): Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WPJournal: MBioPMID: 23341549 January 2013

The large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from…