Publications – Center for Communicable Disease Dynamics

O-Antigen Diversification Masks Identification of Highly Pathogenic Shiga Toxin-Producing Escherichia coli O104:H4-Like Strains.

Author(s): Lang C, Fruth A, Campbell IW, Jenkins C, Smith P, Strockbine N, Weill FX, Nübel U, Grad YH, Waldor MK, Flieger AJournal: Microbiol SpectrPMID: 37212677 May 2023

Shiga toxin-producing Escherichia coli (STEC) can give rise to a range of clinical outcomes from diarrhea to the life-threatening systemic…

CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae.

Author(s): Rubin DHF, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YHJournal: Nat MicrobiolPMID: 36604513 January 2023

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…

Variation in supplemental carbon dioxide requirements defines lineage-specific antibiotic resistance acquisition in Neisseria gonorrhoeae

Author(s): Rubin DH, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YHJournal: bioRxiv February 2022

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…

Testing COVID-19 therapies to prevent progression of mild disease.

Author(s): Lipsitch M, Waldor MKJournal: Lancet Infect DisPMID: 32618282 May 2020

A randomised controlled trial found no significant benefit of lopinavir-ritonavir over placebo in patients with severe corona-virus disease 2019 (COVID-19). Even…

Sequence tag-based analysis of microbial population dynamics.

Author(s): Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MKJournal: Nat MethodsPMID: 25599549 March 2015

We describe sequence tag-based analysis of microbial populations (STAMP) for characterization of pathogen population dynamics during infection. STAMP analyzes the…

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen.

Author(s): Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WPJournal: MBioPMID: 23341549 January 2013

The large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from…