Publications – Center for Communicable Disease Dynamics

The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci

Author(s): D’Aeth JC, van der Linden MPG, McGee L, De Lencastre HC, Turner P, Song J-H, Lo SW, Gladstone RA, Sá-Leão R, Ko KS, Hanage WP, Beall B, Bentley SD, Croucher NJJournal: bioRxiv February 2021

The evolutionary histories of the antibiotic-resistant Streptococcus pneumoniae lineages PMEN3 and PMEN9 were reconstructed using global collections of genomes. In PMEN3, one…

Variable recombination dynamics during the emergence, transmission and ‘disarming’ of a multidrug-resistant pneumococcal clone.

Author(s): Croucher NJ, Hanage WP, Harris SR, McGee L, van der Linden M, de Lencastre H, Sá-Leão R, Song JH, Ko KS, Beall B, Klugman KP, Parkhill J, Tomasz A, Kristinsson KG, Bentley SDJournal: BMC BiolPMID: 24957517 June 2014

Pneumococcal β-lactam resistance was first detected in Iceland in the late 1980s, and subsequently peaked at almost 25% of clinical…