Publications

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

Author(s): Luo Y, Huang CC, Liu Q, Howard N, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri S|Journal: medRxiv| February 2022

The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship…

Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.

Author(s): Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM|Journal: Nat Genet|PMID: 23749189| July 2013

A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple…

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.

Author(s): Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM|Journal: Nat Genet|PMID: 21516081| May 2011

Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We…