Publications – Center for Communicable Disease Dynamics

Deconstructing the parasite multiplication rate of Plasmodium falciparum.

Author(s): Gnangnon B, Duraisingh MT, Buckee COJournal: Trends ParasitolPMID: 34119440 June 2021

Epidemiological indicators describing population-level malaria transmission dynamics are widely used to guide policy recommendations. However, the determinants of malaria outcomes…

Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.

Author(s): Cai F, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee COJournal: PLoS Comput BiolPMID: 32315315 April 2020

The growth of the malaria parasite Plasmodium falciparum in human blood causes all the symptoms of malaria. To proliferate, non-motile…

Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition.

Author(s): Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MTJournal: Proc Natl Acad Sci U S APMID: 29946035 July 2018

Sickle cell trait (AS) confers partial protection against lethal malaria. Multiple mechanisms for this have been proposed, with a recent…

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.

Author(s): Obaldía N 3rd, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti MJournal: Sci RepPMID: 26880111 February 2016

Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to…

A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion.

Author(s): Coleman BI, Skillman KM, Jiang RHY, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BFC, Marti M, Llinás M, Buckee CO, Duraisingh MTJournal: Cell Host MicrobePMID: 25121747 August 2014

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic persistence in human red blood cells, continuously…

Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans.

Author(s): Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MTJournal: Nat CommunPMID: 23535659 January 2013

The macaque malaria parasite Plasmodium knowlesi has recently emerged as an important zoonosis in Southeast Asia. Infections are typically mild…