Publications

Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae.

Author(s): Lehtinen S, Chewapreecha C, Lees J, Hanage WP, Lipsitch M, Croucher NJ, Bentley SD, Turner P, Fraser C, Mostowy RJ|Journal: Sci Adv|PMID: 32671212| May 2020

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move…

Mathematical modelling for antibiotic resistance control policy: do we know enough?

Author(s): Knight GM, Davies NG, Colijn C, Coll F, Donker T, Gifford DR, Glover RE, Jit M, Klemm E, Lehtinen S, Lindsay JA, Lipsitch M, Llewelyn MJ, Mateus ALP, Robotham JV, Sharland M, Stekel D, Yakob L, Atkins KE|Journal: BMC Infect Dis|PMID: 31783803| November 2019

Antibiotics remain the cornerstone of modern medicine. Yet there exists an inherent dilemma in their use: we are able to…

On the evolutionary ecology of multidrug resistance in bacteria.

Author(s): Lehtinen S, Blanquart F, Lipsitch M, Fraser C, with the Maela Pneumococcal Collaboration.|Journal: PLoS Pathog|PMID: 31083687| June 2019

Resistance against different antibiotics appears on the same bacterial strains more often than expected by chance, leading to high frequencies…

The evolution of antibiotic resistance in a structured host population.

Author(s): Blanquart F, Lehtinen S, Lipsitch M, Fraser C|Journal: J R Soc Interface|PMID: 29925579| June 2018

The evolution of antibiotic resistance in opportunistic pathogens such as , or is a major public health problem, as infection…

Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage.

Author(s): Lehtinen S, Blanquart F, Croucher NJ, Turner P, Lipsitch M, Fraser C|Journal: Proc Natl Acad Sci U S A|PMID: 28096340| January 2017

Understanding how changes in antibiotic consumption affect the prevalence of antibiotic resistance in bacterial pathogens is important for public health.…