Publications

Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.

Author(s): Azarian T, Martinez PP, Arnold BJ, Qiu X, Grant LR, Corander J, Fraser C, Croucher NJ, Hammitt LL, Reid R, Santosham M, Weatherholtz RC, Bentley SD, O'Brien KL, Lipsitch M, Hanage WP|Journal: PLoS Biol|PMID: 33091022| October 2020

Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important…

Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae.

Author(s): Lehtinen S, Chewapreecha C, Lees J, Hanage WP, Lipsitch M, Croucher NJ, Bentley SD, Turner P, Fraser C, Mostowy RJ|Journal: Sci Adv|PMID: 32671212| May 2020

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move…

Case-based surveillance of antimicrobial resistance with full susceptibility profiles.

Author(s): Ryu S, Cowling BJ, Wu P, Olesen S, Fraser C, Sun DS, Lipsitch M, Grad YH|Journal: JAC Antimicrob Resist|PMID: 32280945| December 2019

Surveillance of antimicrobial resistance (AMR) is essential for clinical decision-making and for public health authorities to monitor patterns in resistance…

On the evolutionary ecology of multidrug resistance in bacteria.

Author(s): Lehtinen S, Blanquart F, Lipsitch M, Fraser C, with the Maela Pneumococcal Collaboration.|Journal: PLoS Pathog|PMID: 31083687| June 2019

Resistance against different antibiotics appears on the same bacterial strains more often than expected by chance, leading to high frequencies…

The evolution of antibiotic resistance in a structured host population.

Author(s): Blanquart F, Lehtinen S, Lipsitch M, Fraser C|Journal: J R Soc Interface|PMID: 29925579| June 2018

The evolution of antibiotic resistance in opportunistic pathogens such as , or is a major public health problem, as infection…

Frequency-dependent selection in vaccine-associated pneumococcal population dynamics.

Author(s): Corander J, Fraser C, Gutmann MU, Arnold B, Hanage WP, Bentley SD, Lipsitch M, Croucher NJ|Journal: Nat Ecol Evol|PMID: 29038424| December 2017

Many bacterial species are composed of multiple lineages distinguished by extensive variation in gene content. These often cocirculate in the…

Host population structure and treatment frequency maintain balancing selection on drug resistance.

Author(s): Cobey S, Baskerville EB, Colijn C, Hanage W, Fraser C, Lipsitch M|Journal: J R Soc Interface|PMID: 28835542| August 2017

It is a truism that antimicrobial drugs select for resistance, but explaining pathogen- and population-specific variation in patterns of resistance…

Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage.

Author(s): Lehtinen S, Blanquart F, Croucher NJ, Turner P, Lipsitch M, Fraser C|Journal: Proc Natl Acad Sci U S A|PMID: 28096340| January 2017

Understanding how changes in antibiotic consumption affect the prevalence of antibiotic resistance in bacterial pathogens is important for public health.…

Potential Biases in Estimating Absolute and Relative Case-Fatality Risks during Outbreaks.

Author(s): Lipsitch M, Donnelly CA, Fraser C, Blake IM, Cori A, Dorigatti I, Ferguson NM, Garske T, Mills HL, Riley S, Van Kerkhove MD, Hernán MA|Journal: PLoS Negl Trop Dis|PMID: 26181387| July 2015

Estimating the case-fatality risk (CFR)-the probability that a person dies from an infection given that they are a case-is a…

Heterogeneity in the frequency and characteristics of homologous recombination in pneumococcal evolution.

Author(s): Mostowy R, Croucher NJ, Hanage WP, Harris SR, Bentley S, Fraser C|Journal: PLoS Genet|PMID: 24786281| May 2014

The bacterium Streptococcus pneumoniae (pneumococcus) is one of the most important human bacterial pathogens, and a leading cause of morbidity…