Publications

Identifying and alleviating bias due to differential depletion of susceptible people in post-marketing evaluations of COVID-19 vaccines.

Author(s): Kahn R, Schrag SJ, Verani JR, Lipsitch M|Journal: Am J Epidemiol|PMID: 35081612| January 2022

Recent studies have provided key information about SARS-CoV-2 vaccines' efficacy and effectiveness (VE). One important question that remains is whether…

Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California

Author(s): Lewnard JA, Hong VX, Patel MM, Kahn R, Lipsitch M, Tartof SY|Journal: medRxiv| January 2022

The Omicron (B.1.1.529) variant of SARS-CoV-2 has rapidly achieved global dissemination, accounting for most infections in the United States by…

Reduced COVID-19 Hospitalizations among New York City Residents Following Age-Based SARS-CoV-2 Vaccine Eligibility: Evidence from a Regression Discontinuity Design

Author(s): Greene SK, Levin-Rector A, McGibbon E, Baumgartner J, Devinney K, Ternier A, Sell J, Kahn R, Kishore N|Journal: Vaccine X|PMID: 34961848| December 2021

In clinical trials, several SARS-CoV-2 vaccines were shown to reduce risk of severe COVID-19 illness. Local, population-level, real-world evidence of…

Population impact of SARS-CoV-2 variants with enhanced transmissibility and/or partial immune escape.

Author(s): Bushman M, Kahn R, Taylor BP, Lipsitch M, Hanage WP|Journal: Cell|PMID: 34910927| December 2021

SARS-CoV-2 variants of concern exhibit varying degrees of transmissibility and, in some cases, escape from acquired immunity. Much effort has…

Correction: Practical considerations for measuring the effective reproductive number, Rt.

Author(s): Gostic KM, McGough L, Baskerville EB, Abbott S, Joshi K, Tedijanto C, Kahn R, Niehus R, Hay JA, De Salazar PM, Hellewell J, Meakin S, Munday JD, Bosse NI, Sherrat K, Thompson RN, White LF, Huisman JS, Scire J, Bonhoeffer S, Stadler T, Wallinga J, Funk S, Lipsitch M, Cobey S|Journal: PLoS Comput Biol|PMID: 34879070| December 2021

[This corrects the article DOI: 10.1371/journal.pcbi.1008409.].

Estimating vaccine efficacy against transmission via effect on viral load.

Author(s): Kennedy-Shaffer L, Kahn R, Lipsitch M|Journal: Epidemiology|PMID: 34469363| September 2021

Determining policies to end the SARS-CoV-2 pandemic will require an understanding of the efficacy and effectiveness (hereafter, efficacy) of vaccines.…

Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel.

Author(s): Regev-Yochay G, Amit S, Bergwerk M, Lipsitch M, Leshem E, Kahn R, Lustig Y, Cohen C, Doolman R, Ziv A, Novikov I, Rubin C, Gimpelevich I, Huppert A, Rahav G, Afek A, Kreiss Y|Journal: Lancet Reg Health Eur|PMID: 34250518| August 2021

BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing vaccine rollout, and achievement of herd immunity depend on…

Interpreting vaccine efficacy trial results for infection and transmission.

Author(s): Lipsitch M, Kahn R|Journal: Vaccine|PMID: 34130883| July 2021

Randomized controlled trials (RCTs) have shown high efficacy of multiple vaccines against SARS-CoV-2 disease (COVID-19), and recent studies have shown…

Test negative designs with uncertainty, sensitivity, and specificity

Author(s): Johnson EK, Kahn R, Grad YH, Lipsitch M, Larremore DB|Journal: medRxiv| June 2021

Test-negative designs (TNDs) can be used to estimate vaccine effectiveness by comparing the relative rates of the target disease and…

Mathematical modeling to inform vaccination strategies and testing approaches for COVID-19 in nursing homes.

Author(s): Kahn R, Holmdahl I, Reddy S, Jernigan J, Mina MJ, Slayton RB|Journal: Clin Infect Dis|PMID: 34086877| June 2021

Nursing home residents and staff were included in the first phase of COVID-19 vaccination in the United States. Because the…