Publications

Rapid inference of antibiotic susceptibility phenotype of uropathogens using metagenomic sequencing with neighbor typing.

Author(s): Carroll AC, Mortimer L, Ghosh H, Reuter S, Grundmann H, Břinda K, Hanage WP, Li A, Paterson A, Purssell A, Rooney A, Yee NR, Coburn B, Able-Thomas S, Antonio M, McGeer A, MacFadden DR|Journal: Microbiol Spectr|PMID: 39611823| November 2024

Timely diagnostic tools are needed to improve antibiotic treatment. Pairing metagenomic sequencing with genomic neighbor typing algorithms may support rapid…

Using Genetic Distance from Archived Samples for the Prediction of Antibiotic Resistance in Escherichia coli.

Author(s): MacFadden DR, Coburn B, Břinda K, Corbeil A, Daneman N, Fisman D, Lee RS, Lipsitch M, McGeer A, Melano RG, Mubareka S, Hanage WP|Journal: Antimicrob Agents Chemother|PMID: 32152083| March 2020

Rising antibiotic resistance increasingly compromises empiric treatment. Knowing the antibiotic susceptibility of a pathogen's close genetic relative(s) may improve empiric…

Comparing Patient Risk Factors, Sequence Type, and Resistance Loci Identification Approaches for Predicting Antibiotic Resistance in Escherichia coli Bloodstream Infections.

Author(s): MacFadden DR, Melano RG, Coburn B, Tijet N, Hanage WP, Daneman N|Journal: J Clin Microbiol|PMID: 30894438| May 2019

Rapid diagnostic tests of antibiotic resistance are increasingly being developed that identify the presence or absence of antibiotic resistance genes/loci.…