Publications – Center for Communicable Disease Dynamics

Optimal environmental testing frequency for outbreak surveillance

Author(s): Olejarz JW, Oliveira Roster KI, Kissler SM, Lipsitch M, Grad YHJournal: medRxiv September 2023

Public health surveillance for pathogens presents an optimization problem: we require enough sampling to identify intervention-triggering shifts in pathogen epidemiology,…

Surveillance strategies for the detection of new SARS-CoV-2 variants across epidemiological contexts

Author(s): Roster KIO, Kissler SM, Omoregie E, Wang JC, Amin H, Lonardo SD, Hughes S, Grad YHJournal: medRxiv May 2023

Rapid identification of new SARS-CoV-2 variants is a critical component of the public health response to the COVID-19 pandemic. However,…

Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: a retrospective cohort study

Author(s): Hay JA, Kissler SM, Fauver JR, Mack C, Tai CG, Samant RM, Connolly S, Anderson DJ, Khullar G, MacKay M, Patel M, Kelly S, Manhertz A, Eiter I, Salgado D, Baker T, Howard B, Dudley JT, Mason CE, Nair M, Huang Y, DiFiori J, Ho DD, Grubaugh N, Grad YHJournal: ElifePMID: 36383192 November 2022

The combined impact of immunity and SARS-CoV-2 variants on viral kinetics during infections has been unclear. We characterized 1,280 infections…

Impact of respiratory infection and chronic comorbidities on early pediatric antibiotic dispensing in the United States.

Author(s): Kissler SM, Wang B, Mehrotra A, Barnett M, Grad YHJournal: Clin Infect DisPMID: 36196577 October 2022

In the United States, children under age 5 receive high volumes of antibiotics, which may contribute to antibiotic resistance. It…

Infectious disease dynamics and restrictions on social gathering size.

Author(s): Boyer CB, Rumpler E, Kissler SM, Lipsitch MJournal: EpidemicsPMID: 36058184 August 2022

Social gatherings can be an important locus of transmission for many pathogens including SARS-CoV-2. During an outbreak, restricting the size…

Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric Studies.

Author(s): Watson JA, Kissler SM, Day NPJ, Grad YH, White NJJournal: Antimicrob Agents ChemotherPMID: 35736134 June 2022

A consensus methodology for the pharmacometric assessment of candidate SARS-CoV-2 antiviral drugs would be useful for comparing trial results and…

Anticipating Racial/Ethnic Mortality Displacement From COVID-19.

Author(s): Kissler SM, Grad YHJournal: Am J EpidemiolPMID: 35452084 April 2022

Analysis of multiple bacterial species and antibiotic classes reveals large variation in the association between seasonal antibiotic use and resistance.

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YHJournal: PLoS BiolPMID: 35263322 March 2022

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant

Author(s): Hay JA, Kissler SM, Fauver JR, Mack C, Tai CG, Samant RM, Connelly S, Anderson DJ, Khullar G, MacKay M, Patel M, Kelly S, Manhertz A, Eiter I, Salgado D, Baker T, Dudley JT, Mason CE, Ho DD, Grubaugh ND, Grad YHJournal: DASH January 2022

The Omicron SARS-CoV-2 variant is responsible for a major wave of COVID-19, with record case counts reflecting high transmissibility and…

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons.

Author(s): Kissler SM, Fauver JR, Mack C, Tai CG, Breban MI, Watkins AE, Samant RM, Anderson DJ, Metti J, Khullar G, Baits R, MacKay M, Salgado D, Baker T, Dudley JT, Mason CE, Ho DD, Grubaugh ND, Grad YHJournal: N Engl J MedPMID: 34941024 December 2021