Publications

Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric Studies.

Author(s): Watson JA, Kissler SM, Day NPJ, Grad YH, White NJ|Journal: Antimicrob Agents Chemother|PMID: 35736134| June 2022

A consensus methodology for the pharmacometric assessment of candidate SARS-CoV-2 antiviral drugs would be useful for comparing trial results and…

Optimal design for phase 2 studies of SARS-CoV-2 antiviral drugs

Author(s): Watson JA, Kissler S, Day NP, Grad YH, White NJ|Journal: medRxiv| January 2021

There is no agreed methodology for pharmacometric assessment of candidate antiviral drugs in COVID-19. The most widely used measure of…

A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices.

Author(s): Watson JA, Taylor AR, Ashley EA, Dondorp A, Buckee CO, White NJ, Holmes CC|Journal: PLoS Genet|PMID: 33035220| October 2020

Genetic surveillance of malaria parasites supports malaria control programmes, treatment guidelines and elimination strategies. Surveillance studies often pose questions about…

Resolving the cause of recurrent Plasmodium vivax malaria probabilistically.

Author(s): Taylor AR, Watson JA, Chu CS, Puaprasert K, Duanguppama J, Day NPJ, Nosten F, Neafsey DE, Buckee CO, Imwong M, White NJ|Journal: Nat Commun|PMID: 31811128| December 2019

Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a major cause of vivax malaria. However, in endemic areas,…