Publications

SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics.

Author(s): Wikle NB, Tran TN, Gentilesco B, Leighow SM, Albert E, Strong ER, Břinda K, Inam H, Yang F, Hossain S, Chan P, Hanage WP, Messick M, Pritchard JR, Hanks EM, Boni MF|Journal: Sci Adv|PMID: 35080987| January 2022

State-level reopenings in late spring 2020 facilitated the resurgence of severe acute respiratory syndrome coronavirus 2 transmission. Here, we analyze…

Reply to Partridge et al.: Complementary bioinformatics and experimental approaches to investigate the transfer of AMR genes.

Author(s): Che Y, Yang Y, Xu X, Břinda K, Polz MF, Hanage WP, Zhang T|Journal: Proc Natl Acad Sci U S A|PMID: 34453008| August 2021

Reply to Shaw: Challenges for enrichment analysis of AMR gene-bearing plasmids.

Author(s): Che Y, Yang Y, Xu X, Břinda K, Polz MF, Hanage WP, Zhang T|Journal: Proc Natl Acad Sci U S A|PMID: 33975908| May 2021

Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.

Author(s): Che Y, Yang Y, Xu X, Břinda K, Polz MF, Hanage WP, Zhang T|Journal: Proc Natl Acad Sci U S A|PMID: 33526659| February 2021

It is well established that plasmids play an important role in the dissemination of antimicrobial resistance (AMR) genes; however, little…

Using Genetic Distance from Archived Samples for the Prediction of Antibiotic Resistance in Escherichia coli.

Author(s): MacFadden DR, Coburn B, Břinda K, Corbeil A, Daneman N, Fisman D, Lee RS, Lipsitch M, McGeer A, Melano RG, Mubareka S, Hanage WP|Journal: Antimicrob Agents Chemother|PMID: 32152083| March 2020

Rising antibiotic resistance increasingly compromises empiric treatment. Knowing the antibiotic susceptibility of a pathogen's close genetic relative(s) may improve empiric…

Rapid inference of antibiotic resistance and susceptibility by genomic neighbour typing.

Author(s): Břinda K, Callendrello A, Ma KC, MacFadden DR, Charalampous T, Lee RS, Cowley L, Wadsworth CB, Grad YH, Kucherov G, O'Grady J, Baym M, Hanage WP|Journal: Nat Microbiol|PMID: 32042129| February 2020

Surveillance of drug-resistant bacteria is essential for healthcare providers to deliver effective empirical antibiotic therapy. However, traditional molecular epidemiology does…