Publications – Center for Communicable Disease Dynamics

Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru.

Author(s): Tan Q, Huang CC, Becerra MC, Calderon R, Contreras C, Lecca L, Jimenez J, Yataco R, Galea JT, Feng JY, Pan SW, Tseng YH, Huang JR, Zhang Z, Murray MBJournal: Emerg Infect DisPMID: 38781680 June 2024

The World Health Organization's end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease.…

Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.

Author(s): Trevisi L, Brooks MB, Becerra MC, Calderón RI, Contreras CC, Galea JT, Jimenez J, Lecca LW, Yataco RM, Tovar X, Zhang Z, Murray MB, Huang CCJournal: Am J Respir Crit Care MedPMID: 38416532 February 2024

The persistent burden of TB disease emphasizes the need to identify individuals with TB for treatment and those at a…

Utility of Mycobacterium tuberculosis genome sequencing snapshots to assess transmission dynamics over time.

Author(s): Yuen CM, Huang CC, Millones AK, Calderón RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MBJournal: J Infect DisPMID: 37995298 November 2023

We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru for…

Association between overweight/obesity and multidrug-resistant tuberculosis

Author(s): Peinado J, Lecca L, Jimenez J, Calderon R, Yataco R, Becerra MC, Murray MBJournal: Rev Peru Med Exp Salud Publica July 2023

Tuberculosis (TB) affects 8.9 to 11.0 million people and is the cause of death of 1.2 to 1.4 million people…

Latent tuberculosis and depressive symptoms in household contacts of persons with active TB: A cohort study

Author(s): Galea JT, Chu AL, Sweetland A, Jimenez J, Yataco R, Calderon R, Zhang Z, Huang CC, Lecca L, Murray MBJournal: medRxiv November 2022

Depression is common among persons with TB and associated with poor clinical outcomes. However, little is known about the relationship…

Spatial scale of tuberculosis transmission in Lima, Peru.

Author(s): Huang CC, Trevisi L, Becerra MC, Calderón RI, Contreras CC, Jimenez J, Lecca LW, Yataco RM, Zhang Z, Murray MBJournal: Proc Natl Acad Sci U S APMID: 36322726 November 2022

Spatially targeted interventions may be effective alternatives to individual or population-based prevention strategies against tuberculosis (TB). However, their efficacy may…

Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.

Author(s): Asgari S, Luo Y, Huang CC, Zhang Z, Calderon R, Jimenez J, Yataco R, Contreras C, Galea JT, Lecca L, Jones D, Moody DB, Murray MB, Raychaudhuri SJournal: Cell GenomPMID: 35873671 July 2022

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105…

The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis

Author(s): Huang CC, Tan Q, Becerra MC, Calderon R, Chiang SS, Contreras C, Lecca L, Jimenez J, Pérez-Vélez CM, Roya-Pabon CL, Yataco R, Xu H, Zhang Z, Murray MJournal: Am J Respir Crit Care MedPMID: 35608549 June 2022

Although World Health Organization guidelines emphasize contact investigation for tuberculosis-exposed children, data that support chest radiography as a useful tool…

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.

Author(s): Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri SJournal: Nat ImmunolPMID: 34031617 May 2021

Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA…

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.

Author(s): Reijneveld JF, Holzheimer M, Young DC, Lopez K, Suliman S, Jimenez J, Calderon R, Lecca L, Murray MB, Ishikawa E, Yamasaki S, Minnaard AJ, Moody DB, Van Rhijn IJournal: Sci RepPMID: 33479373 January 2021

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To…