Publications – Center for Communicable Disease Dynamics

Contrasting genomic epidemiology between sympatric Plasmodium falciparum and Plasmodium vivax populations.

Author(s): Schwabl P, Camponovo F, Clementson C, Early AM, Laws M, Forero-Peña DA, Noya O, Grillet ME, Vanhove M, Anthony F, James K, Singh N, Cox H, Niles-Robin R, Buckee CO, Neafsey DEJournal: Nat CommunPMID: 39349478 September 2024

The malaria parasites Plasmodium falciparum and Plasmodium vivax differ in key biological processes and associated clinical effects, but consequences on…

Marked heterogeneity in malaria infection risk in a Malian longitudinal cohort

Author(s): LaVerriere E, Johnson ZM, Shieh M, Nziza N, Alter G, Buckee CO, Crompton PD, Traore B, Tran TM, Neafsey DEJournal: medRxiv August 2024

Variation in malaria infection risk, a product of disease exposure and immunity, is poorly understood. We genotypically profiled over 13,000…

Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana.

Author(s): Vanhove M, Schwabl P, Clementson C, Early AM, Laws M, Anthony F, Florimond C, Mathieu L, James K, Knox C, Singh N, Buckee CO, Musset L, Cox H, Niles-Robin R, Neafsey DEJournal: PLoS PathogPMID: 38870266 June 2024

Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. In low transmission…

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis.

Author(s): Carrasquilla M, Early AM, Taylor AR, Knudson Ospina A, Echeverry DF, Anderson TJC, Mancilla E, Aponte S, Cárdenas P, Buckee CO, Rayner JC, Sáenz FE, Neafsey DE, Corredor VJournal: PLoS PathogPMID: 36542676 December 2022

The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most…

Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum.

Author(s): Early AM, Camponovo F, Pelleau S, Cerqueira GC, Lazrek Y, Volney B, Carrasquilla M, de Thoisy B, Buckee CO, Childs LM, Musset L, Neafsey DEJournal: Proc Natl Acad Sci U S APMID: 35867831 July 2022

Successful infectious disease interventions can result in large reductions in parasite prevalence. Such demographic change has fitness implications for individual…

Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: a malaria case study.

Author(s): LaVerriere E, Schwabl P, Carrasquilla M, Taylor AR, Johnson ZM, Shieh M, Panchal R, Straub TJ, Kuzma R, Watson S, Buckee CO, Andrade CM, Portugal S, Crompton PD, Traore B, Rayner JC, Corredor V, James K, Cox H, Early AM, MacInnis BL, Neafsey DEJournal: Mol Ecol ResourPMID: 35437908 April 2022

Multiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for cost-effective monitoring of threatened species and managed wildlife populations,…

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

Author(s): Carrasquilla M, Early AM, Taylor AR, Knudson A, Echeverry DF, Anderson TJ, Mancilla E, Aponte S, Cárdenas P, Buckee CO, Rayner JC, Sáenz FE, Neafsey DE, Corredor VJournal: bioRxiv February 2022

The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most…

Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast.

Author(s): Taylor AR, Echeverry DF, Anderson TJC, Neafsey DE, Buckee COJournal: PLoS GenetPMID: 33196661 November 2020

Characterising connectivity between geographically separated biological populations is a common goal in many fields. Recent approaches to understanding connectivity between…

Resolving the cause of recurrent Plasmodium vivax malaria probabilistically.

Author(s): Taylor AR, Watson JA, Chu CS, Puaprasert K, Duanguppama J, Day NPJ, Nosten F, Neafsey DE, Buckee CO, Imwong M, White NJJournal: Nat CommunPMID: 31811128 December 2019

Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a major cause of vivax malaria. However, in endemic areas,…

Estimating Relatedness Between Malaria Parasites.

Author(s): Taylor AR, Jacob PE, Neafsey DE, Buckee COJournal: GeneticsPMID: 31209105 August 2019

Understanding the relatedness of individuals within or between populations is a common goal in biology. Increasingly, relatedness features in genetic…