Publications

Disseminated gonococcal infection complicated by prosthetic joint infection: case report and genomic and phylogenetic analysis

Author(s): Ogbebor O, Mortimer TD, Fryling K, Zhang JJ, Bhanot N, Grad YHJournal: Open Forum Infect Dis December 2020

Neisseria gonorrhoeae infections have been increasing globally, with prevalence rising across age groups. Here, we report a case of disseminated gonococcal…

Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

Author(s): Mortimer T.D., Grad YH, Ma KC, Mortimer TDJournal: Am J Obstet Gynecol December 2020

Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, must adapt to the variable selective pressures in the…

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Author(s): Ma KC, Mortimer TD, Duckett MA, Hicks AL, Wheeler NE, Sánchez-Busó L, Grad YHJournal: Nat CommunPMID: 33097713 October 2020

The emergence of resistance to azithromycin complicates treatment of Neisseria gonorrhoeae, the etiologic agent of gonorrhea. Substantial azithromycin resistance remains…

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.

Author(s): Vegvari C, Grad YH, White PJ, Didelot X, Whittles LK, Scangarella-Oman NE, Mitrani-Gold FS, Dumont E, Perry CR, Gilchrist K, Hossain M, Mortimer TD, Anderson RM, Gardiner DJournal: Euro SurveillPMID: 33124551 October 2020

BackgroundThe first cases of extensively drug resistant gonorrhoea were recorded in the United Kingdom in 2018. There is a public…

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates.

Author(s): Ma KC, Mortimer TD, Grad YHJournal: MBioPMID: 32843551 August 2020

Lyu and Moseng et al. used cryo-electron microscopy to characterize key residues involved in drug binding by mosaic-like MtrD efflux…

The distribution and spread of susceptible and resistant Neisseria gonorrhoeae across demographic groups in a major metropolitan center.

Author(s): Mortimer TD, Pathela P, Crawley A, Rakeman JL, Lin Y, Harris SR, Blank S, Schillinger JA, Grad YHJournal: Clin Infect DisPMID: 32829411 August 2020

Genomic epidemiology studies of gonorrhea in the United States have primarily focused on national surveillance for antibiotic resistance, and patterns…

Disseminated gonococcal infection complicated by prosthetic joint infection: case report and genomic and phylogenetic analysis

Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates.

The distribution and spread of susceptible and resistant Neisseria gonorrhoeae across demographic groups in a major metropolitan center.

Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae.

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates.