Publications – Center for Communicable Disease Dynamics

Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.

Author(s): Azarian T, Martinez PP, Arnold BJ, Qiu X, Grant LR, Corander J, Fraser C, Croucher NJ, Hammitt LL, Reid R, Santosham M, Weatherholtz RC, Bentley SD, O'Brien KL, Lipsitch M, Hanage WPJournal: PLoS BiolPMID: 33091022 October 2020

Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important…

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.

Author(s): Azarian T, Grant LR, Arnold BJ, Hammitt LL, Reid R, Santosham M, Weatherholtz R, Goklish N, Thompson CM, Bentley SD, O'Brien KL, Hanage WP, Lipsitch MJournal: PLoS PathogPMID: 29617440 April 2018

In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes…

Association of Pneumococcal Protein Antigen Serology With Age and Antigenic Profile of Colonizing Isolates.

Author(s): Azarian T, Grant LR, Georgieva M, Hammitt LL, Reid R, Bentley SD, Goldblatt D, Santosham M, Weatherholtz R, Burbidge P, Goklish N, Thompson CM, Hanage WP, O'Brien KL, Lipsitch MJournal: J Infect DisPMID: 28035010 March 2017

Several Streptococcus pneumoniae proteins play a role in pathogenesis and are being investigated as vaccine targets. It is largely unknown…

Nontypeable pneumococcal isolates among navajo and white mountain apache communities: are these really a cause of invasive disease?

Author(s): Scott JR, Hinds J, Gould KA, Millar EV, Reid R, Santosham M, O'Brien KL, Hanage WPJournal: J Infect DisPMID: 22536000 July 2012

Pneumococci could evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype capsule genes or by downregulating capsule production.…

Pneumococcal sequence type replacement among American Indian children: a comparison of pre- and routine-PCV7 eras.

Author(s): Scott JR, Hanage WP, Lipsitch M, Millar EV, Moulton LH, Hinds J, Reid R, Santosham M, O'Brien KLJournal: VaccinePMID: 22094283 March 2012

Multi-locus sequence typing (MLST) of pneumococcal isolates collected during an efficacy trial of the 7-valent pneumococcal conjugate vaccine (PCV7) among…

Impact of more than a decade of pneumococcal conjugate vaccine use on carriage and invasive potential in Native American communities.

Author(s): Scott JR, Millar EV, Lipsitch M, Moulton LH, Weatherholtz R, Perilla MJ, Jackson DM, Beall B, Craig MJ, Reid R, Santosham M, O'Brien KLJournal: J Infect DisPMID: 22128315 January 2012

We assessed the impact of 12 years of pneumococcal conjugate vaccine (PCV7) use on pneumococcal nasopharyngeal carriage and serotype-specific invasive…