Publications

The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci

Author(s): D’Aeth JC, van der Linden MPG, McGee L, De Lencastre HC, Turner P, Song J-H, Lo SW, Gladstone RA, Sá-Leão R, Ko KS, Hanage WP, Beall B, Bentley SD, Croucher NJJournal: bioRxiv February 2021

The evolutionary histories of the antibiotic-resistant Streptococcus pneumoniae lineages PMEN3 and PMEN9 were reconstructed using global collections of genomes. In PMEN3, one…

Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes.

Author(s): Che Y, Yang Y, Xu X, Břinda K, Polz MF, Hanage WP, Zhang TJournal: Proc Natl Acad Sci U S APMID: 33526659 February 2021

It is well established that plasmids play an important role in the dissemination of antimicrobial resistance (AMR) genes; however, little…

Optimal SARS-CoV-2 vaccine allocation using real-time seroprevalence estimates in Rhode Island and Massachusetts.

Author(s): Tran TN, Wikle N, Albert J, Inam H, Strong E, Břinda K, Leighow SM, Yang F, Hossain S, Pritchard JR, Chan P, Hanage WP, Hanks EM, Boni MFJournal: medRxivPMID: 33469599 January 2021

As three SARS-CoV-2 vaccines come to market in Europe and North America in the winter of 2020-2021, distribution networks will…

Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures.

Author(s): Harrow GL, Lees JA, Hanage WP, Lipsitch M, Corander J, Colijn C, Croucher NJJournal: ISME JPMID: 33408365 January 2021

Streptococcus pneumoniae can be divided into many strains, each a distinct set of isolates sharing similar core and accessory genomes,…

Transmission of SARS-CoV-2 before and after symptom onset: impact of nonpharmaceutical interventions in China

Author(s): Bushman M, Worby C, Chang H.-H, Kraemer M, Hanage WPJournal: medRxiv December 2020

Nonpharmaceutical interventions, such as contact tracing and quarantine, are currently the primary means of controlling the spread of SARS-CoV-2; however,…

Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications.

Author(s): Levin AT, Hanage WP, Owusu-Boaitey N, Cochran KB, Walsh SP, Meyerowitz-Katz GJournal: Eur J EpidemiolPMID: 33289900 December 2020

Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect vulnerable age groups.…

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.

Author(s): Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZJournal: N Engl J MedPMID: 33176080 December 2020

A 45-year-old man with severe antiphospholipid syndrome complicated by diffuse alveolar hemorrhage, who was receiving anticoagulation therapy, glucocorticoids, cyclophosphamide, and…