A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices

Author(s): James A Watson, Aimee R Taylor, Elizabeth A Ashley, Arjen Dondorp, Caroline O Buckee, Nicholas J White, Chris C HolmesJournal: PLoS GenetPMID: 33035220 October 2020
Genetic surveillance of malaria parasites supports malaria control programmes, treatment guidelines and elimination strategies. Surveillance studies often pose questions about…

Participatory syndromic surveillance as a tool for tracking COVID-19 in Bangladesh

Author(s): Ayesha S Mahmud, Anir Chowdhury, Ramiz Uddin, Kawsar Hossain Sojib, Shayan Chowdhury, Md. Tanvir Quader, Sangita Paul, Md. Sheikh Saidy, Kenth Engo-Monsen, Caroline O BuckeeJournal: medRxiv September 2020
Limitations in laboratory diagnostic capacity and reporting delays have hampered efforts to mitigate and control the ongoing coronavirus disease 2019…

Incorporating human mobility data improves forecasts of Dengue fever in Thailand

Author(s): Mathew V Kiang, Mauricio Santillana, Jarvis T Chen, Jukka-Pekka Onnela, Nancy Krieger, Kenth Engo-Monsen, Nattwut Ekapirat, Darin Areechokchai, Richard Maude, Caroline O BuckeeJournal: medRxiv July 2020
Over 390 million people worldwide are infected with dengue fever each year. In the absence of an effective vaccine for…

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

Author(s): W. Robert Shaw, Inga E. Holmdahl, Maurice A. Itoe, Kristine Werling, Meghan Marquette, Douglas G. Paton, Naresh Singh, Caroline O Buckee, Lauren M. Childs, Flaminia CatterucciaJournal: bioRxiv July 2020
Many mosquito species, including the major malaria vector Anopheles gambiae, naturally undergo multiple reproductive cycles of blood feeding, egg development…

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

Author(s): Nyamekye Obeng-Adjei, Daniel B Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, Safiatou Doumbo, Takele B. Yazew, Kassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, Caroline O Buckee, Thomas Lavstsen, Peter D. Crompton, Tuan M. TranJournal: bioRxiv February 2020
Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to the microvasculature mediated via specific…

Plasmodium falciparum population genetic complexity influences transcriptional profile and immune recognition of highly related genotypic clusters

Author(s): Amy K. Bei, Daniel B Larremore, Kazutoyo Miura, Ababacar Diouf, Nicholas K. Baro, Rachel F. Daniels, Allison Griggs, Eli L. Moss, Daniel E. Neafsey, Awa B. Deme, Mouhamad Sy, Stephen Schaffner, Ambroise D. Ahouidi, Daouda Ndiaye, Tandakha Dieye, Souleymane Mboup, Caroline O Buckee, Sarah K. Volkman, Carole A. Long, Dyann F. WirthJournal: bioRxiv January 2020
As transmission intensity has declined in Senegal, so has the genetic complexity of circulating Plasmodium falciparum parasites, resulting in specific…