Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

Author(s): Koji Yahara, Kevin C. Ma, Tatum D. Mortimer, Ken Shimuta, Shu-ichi Nakayama, Aki Hirabayashi, Masato Suzuki, Michio Jinnai, Hitomi Ohya, Toshiro Kuroki, Yuko Watanabe, Mitsuru Yasuda, Takashi Deguchi, Vegard Eldholm, Odile B Harrison, Martin C. J. Maiden, Yonatan H. Grad, Makoto OhnishiJournal: bioRxiv October 2020
Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901,…

Viral dynamics of SARS-CoV-2 infection and the predictive value of repeat testing

Author(s): Stephen M Kissler, Joseph R. Fauver, Christina Mack, Caroline Tai, Kristin Y. Shiue, Chaney Kalinich, Sarah Jednak, Isabel Ott, Chantal Vogels, Jay Wohlgemuth, James Weisberger, John DiFiori, Deverick J. Anderson, Jimmie Mancell, David Ho, Nathan D. Grubaugh, Yonatan H. GradJournal: medRxiv October 2020
SARS-CoV-2 diagnostics that report viral RNA concentrations can be used to determine a patient's stage of infection, but this potential…

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

Author(s): Melinda M. Ashcroft, Eric P. F. Chow, Darren Y. J. Lee, Vesna De Petra, Maree Soumilas, Marlene Tschaepe, Lei Zhang, Danielle J. Ingle, George Taiaroa, Allison L Hicks, Yonatan H. Grad, Benjamin P. Howden, Christopher K. Fairley, Deborah A WilliamsonJournal: medRxiv August 2020
Mathematical modelling and genomic analyses are powerful methods for investigating the transmission dynamics of Neisseria gonorrhoeae, however, often make the…

A community-driven resource for genomic surveillance of Neisseria gonorrhoeae at Pathogenwatch

Author(s): Leonor Sánchez-Busó, Corin A. Yeats, Ben Taylor, Richard Goater, Anthony Underwood, Khalil Abudahab, Silvia Argimón, Kevin C. Ma, Tatum D. Mortimer, Michelle J. Cole, Yonatan H. Grad, Irene Martin, Brian H. Raphael, William M. Shafer, Gianfranco Spiteri, Katy Town, Teodora Wi, Simon R. Harris, Magnus Unemo, David M. AanensenJournal: bioRxiv July 2020
Antimicrobial resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of…

The role of “spillover” in antibiotic resistance

Author(s): Scott W. Olesen, Marc Lipsitch, Yonatan H. GradJournal: bioRxiv June 2020
Antibiotic use is a key driver of antibiotic resistance. Understanding the quantitative association between antibiotic use and resulting resistance is…

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

Author(s): Kevin C. Ma, Tatum D. Mortimer, Allison L Hicks, Nicole E Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel HF Rubin, Yi Wang, Deborah A Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. GradJournal: bioRxiv May 2020
Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast with the…