A cautionary note on the use of unsupervised machine learning algorithms to characterise malaria parasite population structure from genetic distance matrices

Author(s): James A Watson, Aimee R Taylor, Elizabeth A Ashley, Arjen Dondorp, Caroline O Buckee, Nicholas J White, Chris C HolmesJournal: PLoS GenetPMID: 33035220 October 2020
Genetic surveillance of malaria parasites supports malaria control programmes, treatment guidelines and elimination strategies. Surveillance studies often pose questions about…

Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination

Author(s): Christopher Jacob, Nguyen Thuy-Nhien, Mayfong Mayxay, Richard Maude, Huynh Hong Quang, Bouasy Hongvanthong, Viengxay Viengxay, Thang Ngo Duc, Huy Rekol, Rob van der Pluijm, Lorenz Von Seidlein, Rick Fairhurst, Francois Nosten, Md Amir Hossain, Naomi Park, Scott Goodwin, Pascal Ringwald, Keobouphaphone Chindavongsa, Paul Newton, Elizabeth Ashley, Sonexay Phalivong, Rapeephan Maude, Rithea Leang, Cheah Huch, Le Thanh Dong, Kim-Tuyen Nguyen, Tran Minh Nhat, Tran Tinh Hien, Hoa Nguyen, Nicole Zdrojewski, Sara Canavati, Abdullah Sayeed, Didar Uddin, Caroline Buckee, Caterina Fanello, Marie Onyamboko, Thomas Peto, Rupam Tripura, Chanaki Amaratunga, Aung Myint Thu, Gilles Delmas, Jordi Landier, Nguyen Hoang Chau, Dysoley Lek, James Callery, Podjanee Jittamala, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Aung Pyae Phyo, Frank Smithuis, Khin Lin, Myo Thant, Tin Maung Hlaing, Parthasarathi Satpathi, Sanghamitra Satpathi, Prativa Behera, Amar Tripura, Subrata Baidya, Neena Valecha, Anupkumar Anvikar, Akhter ul Islam, Abul Faiz, Chanon Kunasol, Eleanor Drury, Mihir Kekre, Mozam Ali, Katie Love, Shavanthi Rajatileka, Anna Jeffreys, Kate Rowlands, Christina Hubbart, Mehul Dhorda, Ranitha Vongpromek, Namfon Kotanan, Phrutsamon Wongnak, Jacob Almagro Garcia, Richard Pearson, Cristina Ariani, Thanat Chookajorn, Cinzia Malangone, T Nguyen, Jim Stalker, Ben Jeffery, Jonathan Keatley, Kimberly Johnson, Dawn Muddyman, Xin Hui Chan, John Sillitoe, Roberto Amato, Victoria Simpson, Sonia Goncalves, Kirk Rockett, Nicholas Day, Arjen Dondorp, Dominic Kwiatkowski, Olivo MiottoJournal: medRxiv October 2020
The use of parasite genetic data by National Malaria Control Programmes (NMCPs) is currently limited, and typically focused on specific…