Model-informed COVID-19 vaccine prioritization strategies by age and serostatus. Author(s): Bubar KM, Reinholt K, Kissler SM, Lipsitch M, Cobey S, Grad YH, Larremore DB|Journal: Science|PMID: 33479118| January 2021 Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical…
Practical considerations for measuring the effective reproductive number, Rt. Author(s): Gostic KM, McGough L, Baskerville EB, Abbott S, Joshi K, Tedijanto C, Kahn R, Niehus R, Hay JA, De Salazar PM, Hellewell J, Meakin S, Munday JD, Bosse NI, Sherrat K, Thompson RN, White LF, Huisman JS, Scire J, Bonhoeffer S, Stadler T, Wallinga J, Funk S, Lipsitch M, Cobey S|Journal: PLoS Comput Biol|PMID: 33301457| December 2020 Estimation of the effective reproductive number Rt is important for detecting changes in disease transmission over time. During the Coronavirus…
Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine. Author(s): Cai FY, Fussell T, Cobey S, Lipsitch M|Journal: PLoS Comput Biol|PMID: 30273332| October 2018 For encapsulated bacteria such as Streptococcus pneumoniae, asymptomatic carriage is more common and longer in duration than disease, and hence…
Host population structure and treatment frequency maintain balancing selection on drug resistance. Author(s): Cobey S, Baskerville EB, Colijn C, Hanage W, Fraser C, Lipsitch M|Journal: J R Soc Interface|PMID: 28835542| August 2017 It is a truism that antimicrobial drugs select for resistance, but explaining pathogen- and population-specific variation in patterns of resistance…
Viral factors in influenza pandemic risk assessment. Author(s): Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA|Journal: Elife|PMID: 27834632| November 2016 The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of…
Pathogen diversity and hidden regimes of apparent competition. Author(s): Cobey S, Lipsitch M|Journal: Am Nat|PMID: 23234842| January 2013 Competition through cross-reacting host immune responses, a form of apparent competition, is a major driver of pathogen evolution and diversity.…
Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes. Author(s): Cobey S, Lipsitch M|Journal: Science|PMID: 22383809| March 2012 Over 90 capsular serotypes of Streptococcus pneumoniae, a common nasopharyngeal colonizer and major cause of pneumonia, bacteremia, and meningitis, are…
Predicting the epidemic sizes of influenza A/H1N1, A/H3N2, and B: a statistical method. Author(s): Goldstein E, Cobey S, Takahashi S, Miller JC, Lipsitch M|Journal: PLoS Med|PMID: 21750666| July 2011 The epidemic sizes of influenza A/H3N2, A/H1N1, and B infections vary from year to year in the United States. We…
