Publications

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.

Author(s): Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S|Journal: Nature|PMID: 35545678| May 2022

Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

Author(s): Luo Y, Huang CC, Liu Q, Howard N, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri S|Journal: medRxiv| February 2022

The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship…

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

Author(s): Nathan A, Asgari S, Ishigaki K, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price A, Lecca L, Murray MB, Moody DB, Raychaudhuri S|Journal: bioRxiv| July 2021

Many non-coding genetic variants cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…