Publications

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

Author(s): Luo Y, Huang CC, Howard NC, Wang X, Liu Q, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Raman S, Ramnarine AK, Mayfield JA, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri SJournal: Nat CommunPMID: 39613754 November 2024

Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We…

Microbiological Aspects and Clinical Impact of Lower Lung Field Tuberculosis: an Observational Cohort Study in Peru.

Author(s): Tan Q, Huang CC, Calderon R, Lecca L, Mendoza M, Rocha GR, Tintaya K, Tovar X, Feng JY, Pan SW, Tseng YH, Huang JR, Zhang Z, Murray MBJournal: Int J Infect DisPMID: 39491717 November 2024

Approximately 40% of tuberculosis (TB) cases remain undiagnosed globally. Lower lung field tuberculosis (LLF TB) presents atypically and is often…

Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru.

Author(s): Tan Q, Huang CC, Becerra MC, Calderon R, Contreras C, Lecca L, Jimenez J, Yataco R, Galea JT, Feng JY, Pan SW, Tseng YH, Huang JR, Zhang Z, Murray MBJournal: Emerg Infect DisPMID: 38781680 June 2024

The World Health Organization's end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease.…

Utility of Mycobacterium tuberculosis genome sequencing snapshots to assess transmission dynamics over time.

Author(s): Yuen CM, Huang CC, Millones AK, Calderón RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MBJournal: J Infect DisPMID: 37995298 November 2023

We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru for…

Association between overweight/obesity and multidrug-resistant tuberculosis

Author(s): Peinado J, Lecca L, Jimenez J, Calderon R, Yataco R, Becerra MC, Murray MBJournal: Rev Peru Med Exp Salud Publica July 2023

Tuberculosis (TB) affects 8.9 to 11.0 million people and is the cause of death of 1.2 to 1.4 million people…

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

Author(s): Suliman S, Nieto-Caballero VE, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, Leon SR, Calderón RI, Lecca L, Murray M, Rhijn IV, Raychaudhuri S, Moody DB, Gutierrez-Arcelus MJournal: medRxiv July 2023

A quarter of humanity is estimated to be latently infected with Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing…

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

Microbiological Aspects and Clinical Impact of Lower Lung Field Tuberculosis: an Observational Cohort Study in Peru.

Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru.

Utility of Mycobacterium tuberculosis genome sequencing snapshots to assess transmission dynamics over time.

Association between overweight/obesity and multidrug-resistant tuberculosis

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

Latent tuberculosis and depressive symptoms in household contacts of persons with active TB: A cohort study

Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.

The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.