Publications – Center for Communicable Disease Dynamics

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

Author(s): Nathan A, Asgari S, Ishigaki K, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price A, Lecca L, Murray MB, Moody DB, Raychaudhuri SJournal: bioRxiv July 2021

Many non-coding genetic variants cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.

Author(s): Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri SJournal: Nat ImmunolPMID: 34031617 May 2021

Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA…

A sex-specific evolutionary interaction between ADCY9 and CETP

Author(s): Gamache I, Legault MA, Grenier JC, Sanchez R, Rhéaume E, Asgari S, Barhdadi A, Zada YF, Trochet H, Luo Y, Lecca L, Murray M, Raychaudhuri S, Tardif JC, Dubé MP, Hussin JGJournal: bioRxiv May 2021

Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 (ADCY9) gene and clinical responses to the…

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

Author(s): Suliman S, Kjer-Nielsen L, Iwany S, Lopez K, Loh L, Kedzierska K, Ocampo TA, Corbett A, McCluskey J, Rossjohn J, Leon S, Calderon R, Lecca L, Murray MB, Moody B, Rhijn IVJournal: bioRxiv March 2021

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT…

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.

Author(s): Reijneveld JF, Holzheimer M, Young DC, Lopez K, Suliman S, Jimenez J, Calderon R, Lecca L, Murray MB, Ishikawa E, Yamasaki S, Minnaard AJ, Moody DB, Van Rhijn IJournal: Sci RepPMID: 33479373 January 2021

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To…

Children as sentinels of tuberculosis transmission: disease mapping of programmatic data.

Author(s): Gunasekera KS, Zelner J, Becerra MC, Contreras C, Franke MF, Lecca L, Murray MB, Warren JL, Cohen TJournal: BMC MedPMID: 32873309 September 2020

Identifying hotspots of tuberculosis transmission can inform spatially targeted active case-finding interventions. While national tuberculosis programs maintain notification registers which…

Detection of Mycobacterium Tuberculosis DNA in Buccal Swab Samples from Children in Lima, Peru.

Author(s): Flores JA, Calderon R, Mesman AW, Soto M, Coit J, Aliaga J, Mendoza M, Leon SR, Konda K, Mestanza FM, Mendoza CJ, Lecca L, Murray MB, Holmberg RCJournal: Pediatr Infect Dis JPMID: 32675773 July 2020

We examined Mycobacterium tuberculosis DNA detection from buccal swab samples collected from children in Lima, Peru. DNA was extracted and…

A positively selected FBN1 missense variant reduces height in Peruvian individuals.

Author(s): Asgari S, Luo Y, Akbari A, Belbin GM, Li X, Harris DN, Selig M, Bartell E, Calderon R, Slowikowski K, Contreras C, Yataco R, Galea JT, Jimenez J, Coit JM, Farroñay C, Nazarian RM, O'Connor TD, Dietz HC, Hirschhorn JN, Guio H, Lecca L, Kenny EE, Freeman EE, Murray MB, Raychaudhuri SJournal: NaturePMID: 32499652 May 2020

On average, Peruvian individuals are among the shortest in the world. Here we show that Native American ancestry is associated…

Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru.

Author(s): Huang CC, Chu AL, Becerra MC, Galea JT, Calderon R, Contreras C, Yataco R, Zhang Z, Lecca L, Murray MBJournal: Emerg Infect DisPMID: 32091363 March 2020

Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other…

CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State.

Author(s): Lopez K, Iwany SK, Suliman S, Reijneveld JF, Ocampo TA, Jimenez J, Calderon R, Lecca L, Murray MB, Moody DB, Van Rhijn IJournal: Front ImmunolPMID: 32117314 February 2020

The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like…