Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.

Author(s): Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri SJournal: NaturePMID: 35545678 May 2022
Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…

The Impact of Vitamin A Deficiency on Tuberculosis Progression.

Author(s): Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MBJournal: Clin Infect DisPMID: 35486953 April 2022
Although previous studies show that vitamin A deficiency is associated with incident tuberculosis disease, the direction of the association has…

Dual TCR-α Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation.

Author(s): Suliman S, Kjer-Nielsen L, Iwany SK, Lopez Tamara K, Loh L, Grzelak L, Kedzierska K, Ocampo TA, Corbett AJ, McCluskey J, Rossjohn J, Leon SR, Calderon R, Lecca-Garcia L, Murray MB, Moody DB, Van Rhijn IJournal: J ImmunolPMID: 35246495 March 2022
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT…