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Publications

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Pan-serotype Reduction in Progression of Streptococcus pneumoniae to Otitis Media After Rollout of Pneumococcal Conjugate Vaccines.

Author(s): Lewnard JA, Givon-Lavi N, Weinberger DM, Lipsitch M, Dagan R|Journal: Clin Infect Dis|PMID: 29020218| November 2017
Reductions in otitis media (OM) burden following rollout of pneumococcal conjugate vaccines (PCVs) have exceeded predictions of vaccine impact. In…

Identifying climate drivers of infectious disease dynamics: recent advances and challenges ahead.

Author(s): Metcalf CJE, Walter KS, Wesolowski A, Buckee CO, Shevliakova E, Tatem AJ, Boos WR, Weinberger DM, Pitzer VE|Journal: Proc Biol Sci|PMID: 28814655| August 2017
Climate change is likely to profoundly modulate the burden of infectious diseases. However, attributing health impacts to a changing climate…

Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model.

Author(s): Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M|Journal: MBio|PMID: 26374118| September 2015
Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease.…

Surface charge of Streptococcus pneumoniae predicts serotype distribution.

Author(s): Li Y, Weinberger DM, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID: 24082068| December 2013
Streptococcus pneumoniae (pneumococcus) frequently colonizes the human nasopharynx and is an important cause of pneumonia, meningitis, sinusitis, and otitis media.…

Using pneumococcal carriage data to monitor postvaccination changes in invasive disease.

Author(s): Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EA, Feikin DR|Journal: Am J Epidemiol|PMID: 24013204| November 2013
Pneumococcal conjugate vaccines (PCVs) have been introduced worldwide. However, few developing countries have high-quality surveillance systems available for monitoring vaccine…

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.

Author(s): Hyams C, Trzciński K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS|Journal: Infect Immun|PMID: 23147038| January 2013
Different capsular serotypes of Streptococcus pneumoniae vary markedly in their ability to cause invasive infection, but the reasons why are…

Estimating rates of carriage acquisition and clearance and competitive ability for pneumococcal serotypes in Kenya with a Markov transition model.

Author(s): Lipsitch M, Abdullahi O, DʼAmour A, Xie W, Weinberger DM, Tchetgen Tchetgen E, Scott JA|Journal: Epidemiology|PMID: 22441543| July 2012
There are more than 90 serotypes of Streptococcus pneumoniae, with varying biologic and epidemiologic properties. Animal studies suggest that carriage…

Serotype replacement in disease after pneumococcal vaccination.

Author(s): Weinberger DM, Malley R, Lipsitch M|Journal: Lancet|PMID: 21492929| December 2011
Vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) has significantly reduced the burden of pneumococcal disease and has had an important…

Prediction of serotypes causing invasive pneumococcal disease in unvaccinated and vaccinated populations.

Author(s): Weinberger DM, Harboe ZB, Flasche S, Scott JA, Lipsitch M|Journal: Epidemiology|PMID: 21646962| March 2011
Before the introduction of the heptavalent pneumococcal conjugate vaccine (Prevnar-7), the relative prevalence of serotypes of Streptococcus pneumoniae was fairly…

Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis.

Author(s): Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M|Journal: Clin Infect Dis|PMID: 20715907| September 2010
The 92 capsular serotypes of Streptococcus pneumoniae differ greatly in nasopharyngeal carriage prevalence, invasiveness, and disease incidence. There has been…
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