Publications – Center for Communicable Disease Dynamics

Large variation in the association between seasonal antibiotic use and resistance across multiple bacterial species and antibiotic classes

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YHJournal: medRxiv December 2020

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

SARS-CoV-2 viral dynamics in acute infections

Author(s): Kissler SM, Fauver JR, Mack C, Olesen SW, Tai C, Shiue KY, Kalinich C, Jednak S, Ott I, Vogels C, Wohlgemuth J, Weisberger J, DiFiori J, Anderson DJ, Mancell J, Ho D, Grubaugh ND, Grad YHJournal: medRxiv December 2020

SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level viral RNA shedding. The…

The role of “spillover” in antibiotic resistance.

Author(s): Olesen SW, Lipsitch M, Grad YHJournal: Proc Natl Acad Sci U S APMID: 33139558 November 2020

Antibiotic use is a key driver of antibiotic resistance. Understanding the quantitative association between antibiotic use and resulting resistance is…

Response to comment on ‘The distribution of antibiotic use and its association with antibiotic resistance’.

Author(s): Olesen SW, Lipsitch M, Grad YHJournal: ElifePMID: 31050649 August 2019

We are writing to reply to the comment by Pouwels et al., 2019 about our recent study (Olesen et al.,…

Levels of outpatient prescribing for four major antibiotic classes and rates of septicemia hospitalization in adults in different US states – a statistical analysis.

Author(s): Goldstein E, Olesen SW, Karaca Z, Steiner CA, Viboud C, Lipsitch MJournal: BMC Public HealthPMID: 31426780 August 2019

Rates of sepsis/septicemia hospitalization in the US have risen significantly during recent years. Antibiotic resistance and use may contribute to…

The distribution of antibiotic use and its association with antibiotic resistance.

Author(s): Olesen SW, Barnett ML, MacFadden DR, Brownstein JS, Hernández-Díaz S, Lipsitch M, Grad YHJournal: ElifePMID: 30560781 December 2018

Antibiotic use is a primary driver of antibiotic resistance. However, antibiotic use can be distributed in different ways in a…

Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora.

Author(s): Tedijanto C, Olesen SW, Grad YH, Lipsitch MJournal: Proc Natl Acad Sci U S APMID: 30559213 December 2018

Bystander selection-the selective pressure for resistance exerted by antibiotics on microbes that are not the target pathogen of treatment-is critical…

Racial/Ethnic Disparities in Antimicrobial Drug Use, United States, 2014-2015.

Author(s): Olesen SW, Grad YHJournal: Emerg Infect DisPMID: 30334733 November 2018

Using a US nationwide survey, we measured disparities in antimicrobial drug acquisition by race/ethnicity for 2014-2015. White persons reported twice…

Azithromycin susceptibility in Neisseria gonorrhoeae and seasonal macrolide use.

Author(s): Olesen SW, Torrone EA, Papp JR, Kirkcaldy RD, Lipsitch M, Grad YHJournal: J Infect DisPMID: 30239814 September 2018

Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae threatens current treatment recommendations, but the cause of this rise is not well understood.…

Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: observational study.

Author(s): Olesen SW, Barnett ML, MacFadden DR, Lipsitch M, Grad YHJournal: BMJPMID: 30054353 July 2018

To identify temporal trends in outpatient antibiotic use and antibiotic prescribing practice among older adults in a high income country.