Publications – Center for Communicable Disease Dynamics

Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome-wide association study.

Author(s): Mortimer TD, Zhang JJ, Ma KC, Grad YHJournal: Lancet MicrobePMID: 35544098 May 2022

Neisseria gonorrhoeae poses an urgent public health threat because of increasing antimicrobial resistance; however, much of the circulating population remains…

Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities.

Author(s): Hadjineophytou C, Anonsen JH, Svingerud T, Mortimer TD, Grad YH, Scott NE, Koomey MJournal: MBioPMID: 35471082 April 2022

Protein glycosylation systems are widely recognized in bacteria, including members of the genus . In most bacterial species, the molecular…

Anticipating Racial/Ethnic Mortality Displacement From COVID-19.

Author(s): Kissler SM, Grad YHJournal: Am J EpidemiolPMID: 35452084 April 2022

Analysis of multiple bacterial species and antibiotic classes reveals large variation in the association between seasonal antibiotic use and resistance.

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YHJournal: PLoS BiolPMID: 35263322 March 2022

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

Trends in SARS-CoV-2 seroprevalence in Massachusetts estimated from newborn screening specimens.

Author(s): Ma KC, Hale JE, Grad YH, Alter G, Luzuriaga K, Eaton RB, Fischinger S, Kaur D, Brody R, Siddiqui SM, Leach D, Brown CM, Klevens RM, Madoff L, Comeau AMJournal: Clin Infect DisPMID: 35213690 February 2022

Estimating the cumulative incidence of SARS-CoV-2 is essential for setting public health policies. We leveraged de-identified Massachusetts newborn screening specimens…

Variation in supplemental carbon dioxide requirements defines lineage-specific antibiotic resistance acquisition in Neisseria gonorrhoeae

Author(s): Rubin DH, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YHJournal: bioRxiv February 2022

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…

Evaluating spatially adaptive guidelines for the treatment of gonorrhea to reduce the incidence of gonococcal infection and increase the effective lifespan of antibiotics.

Author(s): Yaesoubi R, Cohen T, Hsu K, Gift TL, St Cyr SB, Salomon JA, Grad YHJournal: PLoS Comput BiolPMID: 35139073 February 2022

In the absence of point-of-care gonorrhea diagnostics that report antibiotic susceptibility, gonorrhea treatment is empiric and determined by standardized guidelines.…

Viral dynamics and duration of PCR positivity of the SARS-CoV-2 Omicron variant

Author(s): Hay JA, Kissler SM, Fauver JR, Mack C, Tai CG, Samant RM, Connelly S, Anderson DJ, Khullar G, MacKay M, Patel M, Kelly S, Manhertz A, Eiter I, Salgado D, Baker T, Dudley JT, Mason CE, Ho DD, Grubaugh ND, Grad YHJournal: DASH January 2022

The Omicron SARS-CoV-2 variant is responsible for a major wave of COVID-19, with record case counts reflecting high transmissibility and…

Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons.

Author(s): Kissler SM, Fauver JR, Mack C, Tai CG, Breban MI, Watkins AE, Samant RM, Anderson DJ, Metti J, Khullar G, Baits R, MacKay M, Salgado D, Baker T, Dudley JT, Mason CE, Ho DD, Grubaugh ND, Grad YHJournal: N Engl J MedPMID: 34941024 December 2021

Post-discharge decolonization of patients harboring methicillin-resistant Staphylococcus aureus (MRSA) USA300 strains: secondary analysis of the CLEAR Trial.

Author(s): Gussin GM, Heim L, Tjoa T, McKinnell JA, Miller LG, Gillen DL, Sater MRA, Grad YH, Singh RD, Huang SSJournal: Infect Control Hosp EpidemiolPMID: 34913422 December 2021

The CLEAR Trial recently found that decolonization reduced infections and hospitalizations in MRSA carriers in the year following hospital discharge.…