Publications – Center for Communicable Disease Dynamics

Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination.

Author(s): Cobey S, Larremore DB, Grad YH, Lipsitch MJournal: Nat Rev ImmunolPMID: 33795856 April 2021

When vaccines are in limited supply, expanding the number of people who receive some vaccine, such as by halving doses…

Reduction in antibiotic prescribing attainable with a gonococcal vaccine.

Author(s): Kissler SM, Mitchell M, Grad YHJournal: Clin Infect DisPMID: 33786582 March 2021

We estimated the fraction of antibiotic prescribing in the US attributable to gonorrhea. Gonorrhea contributes to an outsized proportion of…

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae.

Author(s): Yahara K, Ma KC, Mortimer TD, Shimuta K, Nakayama SI, Hirabayashi A, Suzuki M, Jinnai M, Ohya H, Kuroki T, Watanabe Y, Yasuda M, Deguchi T, Eldholm V, Harrison OB, Maiden MCJ, Grad YH, Ohnishi MJournal: Genome MedPMID: 33785063 March 2021

Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901,…

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys.

Author(s): Larremore DB, Fosdick BK, Bubar KM, Zhang S, Kissler SM, Metcalf CJE, Buckee C, Grad YHJournal: ElifePMID: 33666169 March 2021

Establishing how many people have been infected by SARS-CoV-2 remains an urgent priority for controlling the COVID-19 pandemic. Serological tests…

GPS-estimated foot traffic data and venue selection for COVID-19 serosurveillance studies.

Author(s): Brown TS, Martinez de Salazar Munoz P, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Naranbai V, Garcia Beltran W, Miller TE, Thierauf J, Yang W, Kress D, Stelljes K, Johnson K, Larremore DB, Lennerz J, Iafrate AJ, Balsari S, Buckee CO, Grad YHJournal: medRxivPMID: 33564784 February 2021

Tracking the dynamics and spread of COVID-19 is critical to mounting an effective response to the pandemic. In the absence…

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.

Author(s): Bubar KM, Reinholt K, Kissler SM, Lipsitch M, Cobey S, Grad YH, Larremore DBJournal: SciencePMID: 33479118 January 2021

Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical…

Optimal design for phase 2 studies of SARS-CoV-2 antiviral drugs

Author(s): Watson JA, Kissler S, Day NP, Grad YH, White NJJournal: medRxiv January 2021

There is no agreed methodology for pharmacometric assessment of candidate antiviral drugs in COVID-19. The most widely used measure of…

Large variation in the association between seasonal antibiotic use and resistance across multiple bacterial species and antibiotic classes

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YHJournal: medRxiv December 2020

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

Disseminated Gonococcal Infection Complicated by Prosthetic Joint Infection: Case Report and Genomic and Phylogenetic Analysis.

Author(s): Ogbebor O, Mortimer TD, Fryling K, Zhang JJ, Bhanot N, Grad YHJournal: Open Forum Infect DisPMID: 33553473 December 2020

infections have been increasing globally, with prevalence rising across age groups. In this study, we report a case of disseminated…

Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

Author(s): Mortimer T.D., Grad YH, Ma KC, Mortimer TDJournal: Am J Obstet Gynecol December 2020

Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, must adapt to the variable selective pressures in the…