Publications – Center for Communicable Disease Dynamics

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.

Author(s): Bubar KM, Reinholt K, Kissler SM, Lipsitch M, Cobey S, Grad YH, Larremore DBJournal: SciencePMID: 33479118 January 2021

Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical…

Optimal design for phase 2 studies of SARS-CoV-2 antiviral drugs

Author(s): Watson JA, Kissler S, Day NP, Grad YH, White NJJournal: medRxiv January 2021

There is no agreed methodology for pharmacometric assessment of candidate antiviral drugs in COVID-19. The most widely used measure of…

Large variation in the association between seasonal antibiotic use and resistance across multiple bacterial species and antibiotic classes

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YHJournal: medRxiv December 2020

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

Disseminated gonococcal infection complicated by prosthetic joint infection: case report and genomic and phylogenetic analysis

Author(s): Ogbebor O, Mortimer TD, Fryling K, Zhang JJ, Bhanot N, Grad YHJournal: Open Forum Infect Dis December 2020

Neisseria gonorrhoeae infections have been increasing globally, with prevalence rising across age groups. Here, we report a case of disseminated gonococcal…

Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

Author(s): Mortimer T.D., Grad YH, Ma KC, Mortimer TDJournal: Am J Obstet Gynecol December 2020

Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, must adapt to the variable selective pressures in the…

SARS-CoV-2 viral dynamics in acute infections

Author(s): Kissler SM, Fauver JR, Mack C, Olesen SW, Tai C, Shiue KY, Kalinich C, Jednak S, Ott I, Vogels C, Wohlgemuth J, Weisberger J, DiFiori J, Anderson DJ, Mancell J, Ho D, Grubaugh ND, Grad YHJournal: medRxiv December 2020

SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level viral RNA shedding. The…

The role of “spillover” in antibiotic resistance.

Author(s): Olesen SW, Lipsitch M, Grad YHJournal: Proc Natl Acad Sci U S APMID: 33139558 November 2020

Antibiotic use is a key driver of antibiotic resistance. Understanding the quantitative association between antibiotic use and resulting resistance is…

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Author(s): Ma KC, Mortimer TD, Duckett MA, Hicks AL, Wheeler NE, Sánchez-Busó L, Grad YHJournal: Nat CommunPMID: 33097713 October 2020

The emergence of resistance to azithromycin complicates treatment of Neisseria gonorrhoeae, the etiologic agent of gonorrhea. Substantial azithromycin resistance remains…

Cross-reactive memory T cells and herd immunity to SARS-CoV-2.

Author(s): Lipsitch M, Grad YH, Sette A, Crotty SJournal: Nat Rev ImmunolPMID: 33024281 October 2020

Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both…

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.

Author(s): Vegvari C, Grad YH, White PJ, Didelot X, Whittles LK, Scangarella-Oman NE, Mitrani-Gold FS, Dumont E, Perry CR, Gilchrist K, Hossain M, Mortimer TD, Anderson RM, Gardiner DJournal: Euro SurveillPMID: 33124551 October 2020

BackgroundThe first cases of extensively drug resistant gonorrhoea were recorded in the United Kingdom in 2018. There is a public…