Publications

Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea.

Author(s): Palace SG, Fryling KE, Li Y, Wentworth AJ, Traverso G, Grad YH|Journal: J Antimicrob Chemother|PMID: 34245280| July 2021

Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections…

Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model.

Author(s): Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M|Journal: MBio|PMID: 26374118| September 2015

Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease.…

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.

Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID: 25956132| May 2015

Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…

A modified Janus cassette (Sweet Janus) to improve allelic replacement efficiency by high-stringency negative selection in Streptococcus pneumoniae.

Author(s): Li Y, Thompson CM, Lipsitch M|Journal: PLoS One|PMID: 24959661| June 2014

The Janus cassette permits marker-free allelic replacement or knockout in streptomycin-resistant Streptococcus pneumoniae (pneumococcus) through sequential positive and negative selection.…

Within-host selection is limited by an effective population of Streptococcus pneumoniae during nasopharyngeal colonization.

Author(s): Li Y, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID: 24082074| December 2013

Streptococcus pneumoniae (pneumococcus) is a significant pathogen that frequently colonizes the human nasopharynx. Environmental factors, including antimicrobial use and host…

Surface charge of Streptococcus pneumoniae predicts serotype distribution.

Author(s): Li Y, Weinberger DM, Thompson CM, Trzciński K, Lipsitch M|Journal: Infect Immun|PMID: 24082068| December 2013

Streptococcus pneumoniae (pneumococcus) frequently colonizes the human nasopharynx and is an important cause of pneumonia, meningitis, sinusitis, and otitis media.…

Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID: 23144610| January 2012

Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…