Publications – Center for Communicable Disease Dynamics

Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.

Author(s): Trevisi L, Brooks MB, Becerra MC, Calderón RI, Contreras CC, Galea JT, Jimenez J, Lecca LW, Yataco RM, Tovar X, Zhang Z, Murray MB, Huang CCJournal: Am J Respir Crit Care MedPMID: 38416532 February 2024

The persistent burden of TB disease emphasizes the need to identify individuals with TB for treatment and those at a…

Utility of Mycobacterium tuberculosis genome sequencing snapshots to assess transmission dynamics over time.

Author(s): Yuen CM, Huang CC, Millones AK, Calderón RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MBJournal: J Infect DisPMID: 37995298 November 2023

We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru for…

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

Author(s): Suliman S, Nieto-Caballero VE, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, Leon SR, Calderón RI, Lecca L, Murray M, Rhijn IV, Raychaudhuri S, Moody DB, Gutierrez-Arcelus MJournal: medRxiv July 2023

A quarter of humanity is estimated to be latently infected with Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing…

Latent tuberculosis and depressive symptoms in household contacts of persons with active TB: A cohort study

Author(s): Galea JT, Chu AL, Sweetland A, Jimenez J, Yataco R, Calderon R, Zhang Z, Huang CC, Lecca L, Murray MBJournal: medRxiv November 2022

Depression is common among persons with TB and associated with poor clinical outcomes. However, little is known about the relationship…

Spatial scale of tuberculosis transmission in Lima, Peru.

Author(s): Huang CC, Trevisi L, Becerra MC, Calderón RI, Contreras CC, Jimenez J, Lecca LW, Yataco RM, Zhang Z, Murray MBJournal: Proc Natl Acad Sci U S APMID: 36322726 November 2022

Spatially targeted interventions may be effective alternatives to individual or population-based prevention strategies against tuberculosis (TB). However, their efficacy may…

Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.

Author(s): Asgari S, Luo Y, Huang CC, Zhang Z, Calderon R, Jimenez J, Yataco R, Contreras C, Galea JT, Lecca L, Jones D, Moody DB, Murray MB, Raychaudhuri SJournal: Cell GenomPMID: 35873671 July 2022

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105…

The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis

Author(s): Huang CC, Tan Q, Becerra MC, Calderon R, Chiang SS, Contreras C, Lecca L, Jimenez J, Pérez-Vélez CM, Roya-Pabon CL, Yataco R, Xu H, Zhang Z, Murray MJournal: Am J Respir Crit Care MedPMID: 35608549 June 2022

Although World Health Organization guidelines emphasize contact investigation for tuberculosis-exposed children, data that support chest radiography as a useful tool…

The Impact of Vitamin A Deficiency on Tuberculosis Progression.

Author(s): Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MBJournal: Clin Infect DisPMID: 35486953 April 2022

Although previous studies show that vitamin A deficiency is associated with incident tuberculosis disease, the direction of the association has…

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

Author(s): Luo Y, Huang CC, Liu Q, Howard N, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri SJournal: medRxiv February 2022

The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship…

Prediction Tool to Identify Children at Highest Risk of Tuberculosis Disease Progression Among Those Exposed at Home.

Author(s): Brooks MB, Lecca L, Contreras C, Calderon R, Yataco R, Galea J, Huang CC, Murray MB, Becerra MCJournal: Open Forum Infect DisPMID: 34805431 November 2021

There is a dearth of research to understand which children, among those who are exposed at home to tuberculosis (TB),…