Publications – Center for Communicable Disease Dynamics

Association between overweight/obesity and multidrug-resistant tuberculosis

Author(s): Peinado J, Lecca L, Jimenez J, Calderon R, Yataco R, Becerra MC, Murray MBJournal: Rev Peru Med Exp Salud Publica July 2023

Tuberculosis (TB) affects 8.9 to 11.0 million people and is the cause of death of 1.2 to 1.4 million people…

Latent tuberculosis and depressive symptoms in household contacts of persons with active TB: A cohort study

Author(s): Galea JT, Chu AL, Sweetland A, Jimenez J, Yataco R, Calderon R, Zhang Z, Huang CC, Lecca L, Murray MBJournal: medRxiv November 2022

Depression is common among persons with TB and associated with poor clinical outcomes. However, little is known about the relationship…

Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.

Author(s): Asgari S, Luo Y, Huang CC, Zhang Z, Calderon R, Jimenez J, Yataco R, Contreras C, Galea JT, Lecca L, Jones D, Moody DB, Murray MB, Raychaudhuri SJournal: Cell GenomPMID: 35873671 July 2022

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105…

The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis

Author(s): Huang CC, Tan Q, Becerra MC, Calderon R, Chiang SS, Contreras C, Lecca L, Jimenez J, Pérez-Vélez CM, Roya-Pabon CL, Yataco R, Xu H, Zhang Z, Murray MJournal: Am J Respir Crit Care MedPMID: 35608549 June 2022

Although World Health Organization guidelines emphasize contact investigation for tuberculosis-exposed children, data that support chest radiography as a useful tool…

Dual TCR-α Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation.

Author(s): Suliman S, Kjer-Nielsen L, Iwany SK, Lopez Tamara K, Loh L, Grzelak L, Kedzierska K, Ocampo TA, Corbett AJ, McCluskey J, Rossjohn J, Leon SR, Calderon R, Lecca-Garcia L, Murray MB, Moody DB, Van Rhijn IJournal: J ImmunolPMID: 35246495 March 2022

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT…

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

Author(s): Luo Y, Huang CC, Liu Q, Howard N, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri SJournal: medRxiv February 2022

The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship…

Prediction Tool to Identify Children at Highest Risk of Tuberculosis Disease Progression Among Those Exposed at Home.

Author(s): Brooks MB, Lecca L, Contreras C, Calderon R, Yataco R, Galea J, Huang CC, Murray MB, Becerra MCJournal: Open Forum Infect DisPMID: 34805431 November 2021

There is a dearth of research to understand which children, among those who are exposed at home to tuberculosis (TB),…

Characterization of Drug-Resistant Lipid-Dependent Differentially Detectable Mycobacterium tuberculosis.

Author(s): Mesman AW, Baek SH, Huang CC, Kim YM, Cho SN, Ioerger TR, Barreda NN, Calderon R, Sassetti CM, Murray MBJournal: J Clin MedPMID: 34362035 July 2021

An estimated 15-20% of patients who are treated for pulmonary tuberculosis (TB) are culture-negative at the time of diagnosis. Recent…

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

Author(s): Suliman S, Kjer-Nielsen L, Iwany S, Lopez K, Loh L, Kedzierska K, Ocampo TA, Corbett A, McCluskey J, Rossjohn J, Leon S, Calderon R, Lecca L, Murray MB, Moody B, Rhijn IVJournal: bioRxiv March 2021

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT…

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.

Author(s): Reijneveld JF, Holzheimer M, Young DC, Lopez K, Suliman S, Jimenez J, Calderon R, Lecca L, Murray MB, Ishikawa E, Yamasaki S, Minnaard AJ, Moody DB, Van Rhijn IJournal: Sci RepPMID: 33479373 January 2021

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To…