History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

Author(s): Suliman S, Nieto-Caballero VE, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, Leon SR, Calderón RI, Lecca L, Murray M, Rhijn IV, Raychaudhuri S, Moody DB, Gutierrez-Arcelus MJournal: medRxiv July 2023
A quarter of humanity is estimated to be latently infected with Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing…

Spatial scale of tuberculosis transmission in Lima, Peru.

Author(s): Huang CC, Trevisi L, Becerra MC, Calderón RI, Contreras CC, Jimenez J, Lecca LW, Yataco RM, Zhang Z, Murray MBJournal: Proc Natl Acad Sci U S APMID: 36322726 November 2022
Spatially targeted interventions may be effective alternatives to individual or population-based prevention strategies against tuberculosis (TB). However, their efficacy may…

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.

Author(s): Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri SJournal: Nat ImmunolPMID: 34031617 May 2021
Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA…

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak.

Author(s): Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, Zhang Z, You H, Wu M, Zheng Q, Xiong Y, Xiong H, Wang C, Chen C, Xiong F, Zhang Y, Peng Y, Ge S, Zhen B, Yu T, Wang L, Wang H, Liu Y, Chen Y, Mei J, Gao X, Li Z, Gan L, He C, Shi Y, Qi Y, Yang J, Tenen DG, Chai L, Mucci LA, Santillana M, Cai HJournal: Cancer DiscovPMID: 32345594 April 2020
The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with…