Publications – Center for Communicable Disease Dynamics

Utility of Mycobacterium tuberculosis genome sequencing snapshots to assess transmission dynamics over time.

Author(s): Yuen CM, Huang CC, Millones AK, Calderón RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MBJournal: J Infect DisPMID: 37995298 November 2023

We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru for…

Association between overweight/obesity and multidrug-resistant tuberculosis

Author(s): Peinado J, Lecca L, Jimenez J, Calderon R, Yataco R, Becerra MC, Murray MBJournal: Rev Peru Med Exp Salud Publica July 2023

Tuberculosis (TB) affects 8.9 to 11.0 million people and is the cause of death of 1.2 to 1.4 million people…

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

Author(s): Suliman S, Nieto-Caballero VE, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, Leon SR, Calderón RI, Lecca L, Murray M, Rhijn IV, Raychaudhuri S, Moody DB, Gutierrez-Arcelus MJournal: medRxiv July 2023

A quarter of humanity is estimated to be latently infected with Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing…

Latent tuberculosis and depressive symptoms in household contacts of persons with active TB: A cohort study

Author(s): Galea JT, Chu AL, Sweetland A, Jimenez J, Yataco R, Calderon R, Zhang Z, Huang CC, Lecca L, Murray MBJournal: medRxiv November 2022

Depression is common among persons with TB and associated with poor clinical outcomes. However, little is known about the relationship…

Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk.

Author(s): Asgari S, Luo Y, Huang CC, Zhang Z, Calderon R, Jimenez J, Yataco R, Contreras C, Galea JT, Lecca L, Jones D, Moody DB, Murray MB, Raychaudhuri SJournal: Cell GenomPMID: 35873671 July 2022

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105…

The Contribution of Chest Radiography to the Clinical Management of Children Exposed to Tuberculosis

Author(s): Huang CC, Tan Q, Becerra MC, Calderon R, Chiang SS, Contreras C, Lecca L, Jimenez J, Pérez-Vélez CM, Roya-Pabon CL, Yataco R, Xu H, Zhang Z, Murray MJournal: Am J Respir Crit Care MedPMID: 35608549 June 2022

Although World Health Organization guidelines emphasize contact investigation for tuberculosis-exposed children, data that support chest radiography as a useful tool…

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.

Author(s): Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri SJournal: NaturePMID: 35545678 May 2022

Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…

A FLOT1 host regulatory allele is associated with a recently expanded Mtb clade in patients with tuberculosis

Author(s): Luo Y, Huang CC, Liu Q, Howard N, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri SJournal: medRxiv February 2022

The outcome of infectious diseases may depend on the interaction between human and pathogen genomic variations. We explore this relationship…

Prediction Tool to Identify Children at Highest Risk of Tuberculosis Disease Progression Among Those Exposed at Home.

Author(s): Brooks MB, Lecca L, Contreras C, Calderon R, Yataco R, Galea J, Huang CC, Murray MB, Becerra MCJournal: Open Forum Infect DisPMID: 34805431 November 2021

There is a dearth of research to understand which children, among those who are exposed at home to tuberculosis (TB),…

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

Author(s): Nathan A, Asgari S, Ishigaki K, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price A, Lecca L, Murray MB, Moody DB, Raychaudhuri SJournal: bioRxiv July 2021

Many non-coding genetic variants cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…