Publications

Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model.

Author(s): Trzciński K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M|Journal: MBio|PMID: 26374118| September 2015

Competitive interactions between Streptococcus pneumoniae strains during host colonization could influence the serotype distribution in nasopharyngeal carriage and pneumococcal disease.…

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.

Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID: 25956132| May 2015

Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…

Geographic and temporal trends in antimicrobial nonsusceptibility in Streptococcus pneumoniae in the post-vaccine era in the United States.

Author(s): Link-Gelles R, Thomas A, Lynfield R, Petit S, Schaffner W, Harrison L, Farley MM, Aragon D, Nicols M, Kirley PD, Zansky S, Jorgensen J, Juni BA, Jackson D, Moore MR, Lipsitch M|Journal: J Infect Dis|PMID: 23852588| October 2013

We examined whether observed increases in antibiotic nonsusceptible nonvaccine serotypes after introduction of pneumococcal conjugate vaccine in the United States…

Pathogen diversity and hidden regimes of apparent competition.

Author(s): Cobey S, Lipsitch M|Journal: Am Nat|PMID: 23234842| January 2013

Competition through cross-reacting host immune responses, a form of apparent competition, is a major driver of pathogen evolution and diversity.…

Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes.

Author(s): Cobey S, Lipsitch M|Journal: Science|PMID: 22383809| March 2012

Over 90 capsular serotypes of Streptococcus pneumoniae, a common nasopharyngeal colonizer and major cause of pneumonia, bacteremia, and meningitis, are…