Publications

Targeting imperfect vaccines against drug-resistance determinants: a strategy for countering the rise of drug resistance.

Author(s): Joice R, Lipsitch MJournal: PLoS OnePMID: 23935910 July 2013

The growing prevalence of antimicrobial resistance in major pathogens is outpacing discovery of new antimicrobial classes. Vaccines mitigate the effect…

Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.

Author(s): Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SMJournal: Nat GenetPMID: 23749189 July 2013

A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple…

Broad conditions favor the evolution of phase-variable loci.

Author(s): Palmer ME, Lipsitch M, Moxon ER, Bayliss CDJournal: MBioPMID: 23300246 January 2013

Simple sequence repeat (SSR) tracts produce stochastic on-off switching, or phase variation, in the expression of a panoply of surface…

Vaccine allocation in a declining epidemic.

Author(s): Goldstein E, Wallinga J, Lipsitch MJournal: J R Soc InterfacePMID: 22772378 November 2012

Sizeable quantities of 2009 pandemic influenza A/H1N1 (H1N1pdm) vaccine in the USA became available at the end of 2009 when…

Improving the estimation of influenza-related mortality over a seasonal baseline.

Author(s): Goldstein E, Viboud C, Charu V, Lipsitch MJournal: EpidemiologyPMID: 22992574 November 2012

Existing methods for estimation of mortality attributable to influenza are limited by methodological and data uncertainty. We have used proxies…

Rethinking biosafety in research on potential pandemic pathogens.

Author(s): Lipsitch M, Bloom BRJournal: MBioPMID: 23047752 October 2012

If accidentally released, mammalian-transmissible influenza A/H5N1 viruses could pose a greater threat to public health than possibly any other infectious…

Factors related to increasing prevalence of resistance to ciprofloxacin and other antimicrobial drugs in Neisseria gonorrhoeae, United States.

Author(s): Goldstein E, Kirkcaldy RD, Reshef D, Berman S, Weinstock H, Sabeti P, Del Rio C, Hall G, Hook EW, Lipsitch MJournal: Emerg Infect DisPMID: 22840274 August 2012

Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the…