Publications

Targeting imperfect vaccines against drug-resistance determinants: a strategy for countering the rise of drug resistance.

Author(s): Joice R, Lipsitch M|Journal: PLoS One|PMID: 23935910| July 2013

The growing prevalence of antimicrobial resistance in major pathogens is outpacing discovery of new antimicrobial classes. Vaccines mitigate the effect…

Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.

Author(s): Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM|Journal: Nat Genet|PMID: 23749189| July 2013

A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple…

Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID: 23144610| January 2012

Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.

Author(s): Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM|Journal: Nat Genet|PMID: 21516081| May 2011

Tuberculosis poses a global health emergency, which has been compounded by the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains. We…