Publications – Center for Communicable Disease Dynamics

Historical zoonoses and other changes in host tropism of Staphylococcus aureus, identified by phylogenetic analysis of a population dataset.

Author(s): Shepheard MA, Fleming VM, Connor TR, Corander J, Feil EJ, Fraser C, Hanage WPJournal: PLoS OnePMID: 23667472 May 2013

Staphylococcus aureus exhibits tropisms to many distinct animal hosts. While spillover events can occur wherever there is an interface between…

Rapid pneumococcal evolution in response to clinical interventions.

Author(s): Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP, Bentley SDJournal: SciencePMID: 21273480 January 2011

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing…

What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?

Author(s): Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, Givon-Lavi N, Dagan R, Lipsitch MJournal: J R Soc InterfacePMID: 19940002 June 2010

The rise of antimicrobial resistance in many pathogens presents a major challenge to the treatment and control of infectious diseases.…

HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.

Author(s): Hollingsworth TD, Laeyendecker O, Shirreff G, Donnelly CA, Serwadda D, Wawer MJ, Kiwanuka N, Nalugoda F, Collinson-Streng A, Ssempijja V, Hanage WP, Quinn TC, Gray RH, Fraser CJournal: PLoS PathogPMID: 20463808 May 2010

It has been hypothesized that HIV-1 viral load set-point is a surrogate measure of HIV-1 viral virulence, and that it…