Publications

Models of immune selection for multi-locus antigenic diversity of pathogens.

Author(s): Georgieva M, Buckee CO, Lipsitch MJournal: Nat Rev ImmunolPMID: 30479379 January 2019

It is well accepted that pathogens can evade recognition and elimination by the host immune system by varying their antigenic…

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.

Author(s): Azarian T, Grant LR, Arnold BJ, Hammitt LL, Reid R, Santosham M, Weatherholtz R, Goklish N, Thompson CM, Bentley SD, O'Brien KL, Hanage WP, Lipsitch MJournal: PLoS PathogPMID: 29617440 April 2018

In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes…

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity.

Author(s): Georgieva M, Kagedan L, Lu YJ, Thompson CM, Lipsitch MJournal: MBioPMID: 29535198 March 2018

Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of While this phenomenon is commonly…

Weak Epistasis May Drive Adaptation in Recombining Bacteria.

Author(s): Arnold BJ, Gutmann MU, Grad YH, Sheppard SK, Corander J, Lipsitch M, Hanage WPJournal: GeneticsPMID: 29330348 March 2018

The impact of epistasis on the evolution of multi-locus traits depends on recombination. While sexually reproducing eukaryotes recombine so frequently…

Serotype-specific immune responses to pneumococcal conjugate vaccine among children are significantly correlated by individual: Analysis of randomized controlled trial data.

Author(s): Lipsitch M, Li LM, Patterson S, Trammel J, Juergens C, Gruber WC, Scott DA, Dagan RJournal: VaccinePMID: 29248266 January 2018

The magnitude of an individual's serotype-specific immunoglobulin G (IgG) response to a pneumococcal conjugate vaccine (PCV) has been associated with…

Frequency-dependent selection in vaccine-associated pneumococcal population dynamics.

Author(s): Corander J, Fraser C, Gutmann MU, Arnold B, Hanage WP, Bentley SD, Lipsitch M, Croucher NJJournal: Nat Ecol EvolPMID: 29038424 December 2017

Many bacterial species are composed of multiple lineages distinguished by extensive variation in gene content. These often cocirculate in the…

Exploring the role of competition induced by non-vaccine serotypes for herd protection following pneumococcal vaccination.

Author(s): Masala GL, Lipsitch M, Bottomley C, Flasche SJournal: J R Soc InterfacePMID: 29093131 November 2017

The competitive pressure from non-vaccine serotypes may have helped pneumococcal conjugate vaccines (PCVs) to limit vaccine-type (VT) serotype prevalence. We…