Publications – Center for Communicable Disease Dynamics

Systematic analysis of protein identity between Zika virus and other arthropod-borne viruses.

Author(s): Chang HH, Huber RG, Bond PJ, Grad YH, Camerini D, Maurer-Stroh S, Lipsitch MJournal: Bull World Health OrganPMID: 28670016 July 2017

To analyse the proportions of protein identity between Zika virus and dengue, Japanese encephalitis, yellow fever, West Nile and chikungunya…

Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013.

Author(s): Grad YH, Harris SR, Kirkcaldy RD, Green AG, Marks DS, Bentley SD, Trees D, Lipsitch MJournal: J Infect DisPMID: 27638945 November 2016

Treatment of Neisseria gonorrhoeae infection is empirical and based on population-wide susceptibilities. Increasing antimicrobial resistance underscores the potential importance of…

Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling.

Author(s): Grad YH, Goldstein E, Lipsitch M, White PJJournal: J Infect DisPMID: 26518045 March 2016

The rise in gonococcal antibiotic resistance and the threat of untreatable infection are focusing attention on strategies to limit the…

Origin and proliferation of multiple-drug resistance in bacterial pathogens.

Author(s): Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch MJournal: Microbiol Mol Biol RevPMID: 25652543 March 2015

Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because MDR infections are often significantly harder and more…

Epidemiologic data and pathogen genome sequences: a powerful synergy for public health.

Author(s): Grad YH, Lipsitch MJournal: Genome BiolPMID: 25418119 November 2014

Epidemiologists aim to inform the design of public health interventions with evidence on the evolution, emergence and spread of infectious…

In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

Author(s): Johnson SR, Grad Y, Ganakammal SR, Burroughs M, Frace M, Lipsitch M, Weil R, Trees DJournal: Antimicrob Agents ChemotherPMID: 25199775 November 2014

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment…

Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure.

Author(s): Grad YH, Newman R, Zody M, Yang X, Murphy R, Qu J, Malboeuf CM, Levin JZ, Lipsitch M, DeVincenzo JJournal: J VirolPMID: 24741088 July 2014

Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in infants and young children and…

Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study.

Author(s): Grad YH, Kirkcaldy RD, Trees D, Dordel J, Harris SR, Goldstein E, Weinstock H, Parkhill J, Hanage WP, Bentley S, Lipsitch MJournal: Lancet Infect DisPMID: 24462211 March 2014

The emergence of Neisseria gonorrhoeae with decreased susceptibility to extended spectrum cephalosporins raises the prospect of untreatable gonorrhoea. In the…

Bacterial genomes in epidemiology–present and future.

Author(s): Croucher NJ, Harris SR, Grad YH, Hanage WPJournal: Philos Trans R Soc Lond B Biol SciPMID: 23382424 February 2013

Sequence data are well established in the reconstruction of the phylogenetic and demographic scenarios that have given rise to outbreaks…

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen.

Author(s): Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WPJournal: MBioPMID: 23341549 January 2013

The large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from…