Publications – Center for Communicable Disease Dynamics

The relation between prescribing of different antibiotics and rates of mortality with sepsis in US adults.

Author(s): Goldstein E, Lipsitch MJournal: BMC Infect DisPMID: 32087679 February 2020

Antibiotic use contributes to the rates of sepsis and the associated mortality, particularly through lack of clearance of resistant infections…

Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens.

Author(s): Tedijanto C, Grad YH, Lipsitch MJournal: ElifePMID: 32022685 February 2020

The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in…

Novel methods for the analysis of stepped wedge cluster randomized trials.

Author(s): Kennedy-Shaffer L, de Gruttola V, Lipsitch MJournal: Stat MedPMID: 31876979 December 2019

Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes,…

Levels of outpatient prescribing for four major antibiotic classes and rates of septicemia hospitalization in adults in different US states – a statistical analysis.

Author(s): Goldstein E, Olesen SW, Karaca Z, Steiner CA, Viboud C, Lipsitch MJournal: BMC Public HealthPMID: 31426780 August 2019

Rates of sepsis/septicemia hospitalization in the US have risen significantly during recent years. Antibiotic resistance and use may contribute to…

The distribution of antibiotic use and its association with antibiotic resistance.

Author(s): Olesen SW, Barnett ML, MacFadden DR, Brownstein JS, Hernández-Díaz S, Lipsitch M, Grad YHJournal: ElifePMID: 30560781 December 2018

Antibiotic use is a primary driver of antibiotic resistance. However, antibiotic use can be distributed in different ways in a…

Cost-benefit analysis of vaccination: a comparative analysis of eight approaches for valuing changes to mortality and morbidity risks.

Author(s): Park M, Jit M, Wu JTJournal: BMC MedPMID: 30180901 September 2018

There is increasing interest in estimating the broader benefits of public health interventions beyond those captured in traditional cost-utility analyses.…

Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling.

Author(s): Heidebrecht CL, Podewils LJ, Pym A, Mthiyane T, Cohen TJournal: PLoS OnePMID: 27050561 April 2016

KwaZulu-Natal (KZN) has the highest burden of notified multidrug-resistant tuberculosis (MDR TB) and extensively drug-resistant (XDR) TB cases in South…

Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling.

Author(s): Grad YH, Goldstein E, Lipsitch M, White PJJournal: J Infect DisPMID: 26518045 March 2016

The rise in gonococcal antibiotic resistance and the threat of untreatable infection are focusing attention on strategies to limit the…

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.

Author(s): Obaldía N 3rd, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti MJournal: Sci RepPMID: 26880111 February 2016

Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to…

Identifying the effect of patient sharing on between-hospital genetic differentiation of methicillin-resistant Staphylococcus aureus.

Author(s): Chang HH, Dordel J, Donker T, Worby CJ, Feil EJ, Hanage WP, Bentley SD, Huang SS, Lipsitch MJournal: Genome MedPMID: 26873713 February 2016

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing…