Publications

The relation between prescribing of different antibiotics and rates of mortality with sepsis in US adults.

Author(s): Goldstein E, Lipsitch M|Journal: BMC Infect Dis|PMID: 32087679| February 2020

Antibiotic use contributes to the rates of sepsis and the associated mortality, particularly through lack of clearance of resistant infections…

Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens.

Author(s): Tedijanto C, Grad YH, Lipsitch M|Journal: Elife|PMID: 32022685| February 2020

The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in…

Novel methods for the analysis of stepped wedge cluster randomized trials.

Author(s): Kennedy-Shaffer L, de Gruttola V, Lipsitch M|Journal: Stat Med|PMID: 31876979| December 2019

Stepped wedge cluster randomized trials (SW-CRTs) have become increasingly popular and are used for a variety of interventions and outcomes,…

Levels of outpatient prescribing for four major antibiotic classes and rates of septicemia hospitalization in adults in different US states – a statistical analysis.

Author(s): Goldstein E, Olesen SW, Karaca Z, Steiner CA, Viboud C, Lipsitch M|Journal: BMC Public Health|PMID: 31426780| August 2019

Rates of sepsis/septicemia hospitalization in the US have risen significantly during recent years. Antibiotic resistance and use may contribute to…

The distribution of antibiotic use and its association with antibiotic resistance.

Author(s): Olesen SW, Barnett ML, MacFadden DR, Brownstein JS, Hernández-Díaz S, Lipsitch M, Grad YH|Journal: Elife|PMID: 30560781| December 2018

Antibiotic use is a primary driver of antibiotic resistance. However, antibiotic use can be distributed in different ways in a…

Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling.

Author(s): Grad YH, Goldstein E, Lipsitch M, White PJ|Journal: J Infect Dis|PMID: 26518045| March 2016

The rise in gonococcal antibiotic resistance and the threat of untreatable infection are focusing attention on strategies to limit the…

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.

Author(s): Obaldía N 3rd, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M|Journal: Sci Rep|PMID: 26880111| February 2016

Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to…

Identifying the effect of patient sharing on between-hospital genetic differentiation of methicillin-resistant Staphylococcus aureus.

Author(s): Chang HH, Dordel J, Donker T, Worby CJ, Feil EJ, Hanage WP, Bentley SD, Huang SS, Lipsitch M|Journal: Genome Med|PMID: 26873713| February 2016

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing…

Impact of Host Heterogeneity on the Efficacy of Interventions to Reduce Staphylococcus aureus Carriage.

Author(s): Chang Q, Lipsitch M, Hanage WP|Journal: Infect Control Hosp Epidemiol|PMID: 26598029| February 2016

Staphylococcus aureus is a common cause of bacterial infections worldwide. It is most commonly carried in and transmitted from the…

The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens.

Author(s): Evans NG, Lipsitch M, Levinson M|Journal: J Med Ethics|PMID: 26320212| November 2015

This paper proposes an ethical framework for evaluating biosafety risks of gain-of-function (GOF) experiments that create novel strains of influenza…