Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.

Author(s): Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri SJournal: NaturePMID: 35545678 May 2022
Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated…

Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis

Author(s): Jessica D. Haugen Frenkel, David F. Ackart, Alexandra K. Todd, James E. DiLisio, Siana Hoffman, Samantha Tanner, Dilara Kiran, Megan Murray, Adam Chicco, Andrés Obregón-Henao, Brendan K. Podell, Randall J. BasarabaJournal: NaturePMID: 33004826 October 2020
Tuberculosis (TB) is a chronic inflammatory disease that is often associated with alterations in systemic and cellular metabolism that resolves…

A positively selected FBN1 missense variant reduces height in Peruvian individuals.

Author(s): Asgari S, Luo Y, Akbari A, Belbin GM, Li X, Harris DN, Selig M, Bartell E, Calderon R, Slowikowski K, Contreras C, Yataco R, Galea JT, Jimenez J, Coit JM, Farroñay C, Nazarian RM, O'Connor TD, Dietz HC, Hirschhorn JN, Guio H, Lecca L, Kenny EE, Freeman EE, Murray MB, Raychaudhuri SJournal: NaturePMID: 32499652 May 2020
On average, Peruvian individuals are among the shortest in the world. Here we show that Native American ancestry is associated…