Analysis of multiple bacterial species and antibiotic classes reveals large variation in the association between seasonal antibiotic use and resistance. Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YH|Journal: PLoS Biol|PMID: 35263322| March 2022 Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies. Author(s): Kissler SM, Fauver JR, Mack C, Olesen SW, Tai C, Shiue KY, Kalinich CC, Jednak S, Ott IM, Vogels CBF, Wohlgemuth J, Weisberger J, DiFiori J, Anderson DJ, Mancell J, Ho DD, Grubaugh ND, Grad YH|Journal: PLoS Biol|PMID: 34252080| July 2021 SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding.…
Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae. Author(s): Azarian T, Martinez PP, Arnold BJ, Qiu X, Grant LR, Corander J, Fraser C, Croucher NJ, Hammitt LL, Reid R, Santosham M, Weatherholtz RC, Bentley SD, O'Brien KL, Lipsitch M, Hanage WP|Journal: PLoS Biol|PMID: 33091022| October 2020 Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important…
Combining genomics and epidemiology to track mumps virus transmission in the United States. Author(s): Wohl S, Metsky HC, Schaffner SF, Piantadosi A, Burns M, Lewnard JA, Chak B, Krasilnikova LA, Siddle KJ, Matranga CB, Bankamp B, Hennigan S, Sabina B, Byrne EH, McNall RJ, Shah RR, Qu J, Park DJ, Gharib S, Fitzgerald S, Barreira P, Fleming S, Lett S, Rota PA, Madoff LC, Yozwiak NL, MacInnis BL, Smole S, Grad YH, Sabeti PC|Journal: PLoS Biol|PMID: 32045407| February 2020 Unusually large outbreaks of mumps across the United States in 2016 and 2017 raised questions about the extent of mumps…
Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics. Author(s): Hicks AL, Kissler SM, Lipsitch M, Grad YH|Journal: PLoS Biol|PMID: 31714937| November 2019 The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and…
Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation. Author(s): McAdams D, Wollein Waldetoft K, Tedijanto C, Lipsitch M, Brown SP|Journal: PLoS Biol|PMID: 31095567| June 2019 Rapid point-of-care resistance diagnostics (POC-RD) are a key tool in the fight against antibiotic resistance. By tailoring drug choice to…
Absolute humidity and the seasonal onset of influenza in the continental United States. Author(s): Shaman J, Pitzer VE, Viboud C, Grenfell BT, Lipsitch M|Journal: PLoS Biol|PMID: 20186267| February 2010 Much of the observed wintertime increase of mortality in temperate regions is attributed to seasonal influenza. A recent reanalysis of…
