Publications – Center for Communicable Disease Dynamics

Potential Biases Arising from Epidemic Dynamics in Observational Seroprotection Studies.

Author(s): Kahn R, Kennedy-Shaffer L, Grad YH, Robins JM, Lipsitch MJournal: Am J EpidemiolPMID: 32870977 September 2020

The extent and duration of immunity following SARS-CoV-2 infection are critical outstanding questions about the epidemiology of this novel virus,…

Statistical Properties of Stepped Wedge Cluster-Randomized Trials in Infectious Disease Outbreaks.

Author(s): Kennedy-Shaffer L, Lipsitch MJournal: Am J EpidemiolPMID: 32648891 July 2020

Randomized controlled trials are crucial for the evaluation of interventions such as vaccinations, but the design and analysis of these…

Distinguishing Causation From Correlation in the Use of Correlates of Protection to Evaluate and Develop Influenza Vaccines.

Author(s): Lim WW, Leung NHL, Sullivan SG, Tchetgen Tchetgen EJ, Cowling BJJournal: Am J EpidemiolPMID: 31598648 March 2020

There is increasing attention to the need to identify new immune markers for the evaluation of existing and new influenza…

Reassessing Serosurvey-Based Estimates of the Symptomatic Proportion of Zika Virus Infections.

Author(s): Mitchell PK, Mier-Y-Teran-Romero L, Biggerstaff BJ, Delorey MJ, Aubry M, Cao-Lormeau VM, Lozier MJ, Cauchemez S, Johansson MAJournal: Am J EpidemiolPMID: 30165474 February 2019

Since the 2007 Zika epidemic in the Micronesian state of Yap, it has been apparent that not all people infected…

Accounting for unobserved and differential susceptible time at risk in retrospective studies: response to Dean (2019).

Author(s): Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch MJournal: Am J EpidemiolPMID: 30689694 February 2019

Measurement of Vaccine Direct Effects Under the Test-Negative Design.

Author(s): Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch MJournal: Am J EpidemiolPMID: 30099505 December 2018

Test-negative designs are commonplace in assessments of influenza vaccination effectiveness, estimating this value from the exposure odds ratio of vaccination…

Analyzing Vaccine Trials in Epidemics with Mild and Asymptomatic Infection.

Author(s): Kahn R, Hitchings M, Wang R, Bellan S, Lipsitch MJournal: Am J EpidemiolPMID: 30329134 October 2018

Vaccine efficacy against susceptibility to infection (VES), regardless of symptoms, is an important endpoint of vaccine trials for pathogens with…

Competing Effects Of Indirect Protection And Clustering On The Power Of Cluster-Randomized Controlled Vaccine Trials.

Author(s): Hitchings MDT, Lipsitch M, Wang R, Bellan SEJournal: Am J EpidemiolPMID: 29522080 March 2018

Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.

Author(s): Li L, Wong JY, Wu P, Bond HS, Lau EHY, Sullivan SG, Cowling BJJournal: Am J EpidemiolPMID: 28679157 February 2018

Influenza viruses are associated with a substantial global burden of morbidity and mortality every year. Estimates of influenza-associated mortality often…

Estimating Influenza Vaccine Effectiveness With the Test-Negative Design Using Alternative Control Groups: A Systematic Review and Meta-Analysis.

Author(s): Feng S, Cowling BJ, Kelly H, Sullivan SGJournal: Am J EpidemiolPMID: 28641373 February 2018

One important assumption in case-control studies is that control selection should be independent of exposure. Nevertheless, it has been hypothesized…