The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci

Author(s): D’Aeth JC, van der Linden MPG, McGee L, De Lencastre HC, Turner P, Song J-H, Lo SW, Gladstone RA, Sá-Leão R, Ko KS, Hanage WP, Beall B, Bentley SD, Croucher NJJournal: bioRxiv February 2021
The evolutionary histories of the antibiotic-resistant Streptococcus pneumoniae lineages PMEN3 and PMEN9 were reconstructed using global collections of genomes. In PMEN3, one…

Distinguishing gene flow between malaria parasite populations

Author(s): Brown TS, Taylor AR, Arogbokun O, Buckee CO, Chang HHJournal: bioRxiv January 2021
Measuring gene flow between malaria parasite populations in different geographic locations can provide strategic information for malaria control interventions. Multiple…

A community-driven resource for genomic surveillance of Neisseria gonorrhoeae at Pathogenwatch

Author(s): Leonor Sánchez-Busó, Corin A. Yeats, Ben Taylor, Richard Goater, Anthony Underwood, Khalil Abudahab, Silvia Argimón, Kevin C. Ma, Tatum D. Mortimer, Michelle J. Cole, Yonatan H. Grad, Irene Martin, Brian H. Raphael, William M. Shafer, Gianfranco Spiteri, Katy Town, Teodora Wi, Simon R. Harris, Magnus Unemo, David M. AanensenJournal: bioRxiv July 2020
Antimicrobial resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of…

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

Author(s): Kevin C. Ma, Tatum D. Mortimer, Allison L Hicks, Nicole E Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel HF Rubin, Yi Wang, Deborah A Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. GradJournal: bioRxiv May 2020
Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast with the…

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression

Author(s): Aparna Nathan, Jessica I. Beynor, Yuriy Baglaenko, Sara Suliman, Kazuyoshi Ishigaki, Samira Asgari, Chuan-Chin Huang, Yang Luo, Zibiao Zhang, Kattya Lopez Tamara, Judith Jimenez, Roger I. Calderón, Leonid Lecca, Ildiko van Rhijn, D. Branch Moody, Megan B. Murray, Soumya RaychaudhuriJournal: bioRxiv April 2020
Mycobacterium tuberculosis (M.tb) results in 10 million active tuberculosis (TB) cases and 1.5 million deaths each year, making it the…

Predicting evolution using frequency-dependent selection in bacterial populations

Author(s): Taj Azarian, Pamela P Martinez, Brian J Arnold, Lindsay R Grant, Jukka Corander, Christophe Fraser, Nicholas J. Croucher, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert C Weatherholtz, Stephen D Bentley, Katherine L O’Brien, Marc Lipsitch, William P HanageJournal: bioRxiv February 2020
Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important…

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

Author(s): Nyamekye Obeng-Adjei, Daniel B Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, Safiatou Doumbo, Takele B. Yazew, Kassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, Caroline O Buckee, Thomas Lavstsen, Peter D. Crompton, Tuan M. TranJournal: bioRxiv February 2020
Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to the microvasculature mediated via specific…